RTKN2 Antibody

Code CSB-PA020566GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
RTKN2
Alternative Names
RTKN2 antibody; PLEKHK1Rhotekin-2 antibody; Pleckstrin homology domain-containing family K member 1 antibody; PH domain-containing family K member 1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human RTKN2
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May play an important role in lymphopoiesis.
Gene References into Functions
  1. RTKN2 was upregulated in human bladder cancer tissues and cell lines. Silencing of RTKN2 inhibited proliferation and invasion, and induced cell apoptosis. In addition, knockdown of RTKN2 arrested the cell cycle at the G1 phase via inhibition of the expression of cell cycle-associated proteins. PMID: 27082503
  2. RTKN2 was overexpressed in HCC tissues. RTKN2 served an important role in tumorigenesis and metastasis of HCC. PMID: 27081789
  3. miR-1246 promotes UVB-induced apoptosis by downregulating RTKN2 expression and that UVB-upregulated miR-1246 released RTKN2-dependent resistance to UVB-induced apoptosis by targeting RTKN2 post-transcriptionally in keratinocyte cells. PMID: 24880483
  4. we identified two gene loci associated with rheumatoid arthritis susceptibility- NFKBIE and RTKN2 PMID: 23028356
  5. Cloning and characterization of gene expression of rhotekin-2. PMID: 15504364

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Tissue Specificity
Expressed in lymphocytes, CD4 positive T-cells and bone marrow-derived cells. Also expressed in lung, colon, thymus and brain.
Database Links

HGNC: 19364

KEGG: hsa:219790

UniGene: Hs.58559

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