RXRB Antibody

Code CSB-PA020613GA01HU
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Product Details

Uniprot No. P28702
Target Names RXRB
Alternative Names RXRB antibody; NR2B2 antibody; Retinoic acid receptor RXR-beta antibody; Nuclear receptor subfamily 2 group B member 2 antibody; Retinoid X receptor beta antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human RXRB
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).
Gene References into Functions
  1. A fatty acid-binding protein 7/RXRbeta pathway enhances survival and proliferation in triple-negative breast cancer. PMID: 22322885
  2. polymorphism is unrelated to schizophrenia or alcoholism. PMID: 11840500
  3. Family studies revealed significant linkage disequilibrium between the RXRB alleles and a number of HLA-DPB1 alleles. PMID: 12175732
  4. Diminished RXRbeta expression might be related to prostate cancer progression. Because responsiveness to retinoic acid treatments depends on expression of different receptors, it is important to study their expression before therapy. PMID: 12514092
  5. partial dissociation of TR/retinoid X receptor heterodimer complex from the TRE is involved in the suppression of transcription induced by polychlorinated biphenyls PMID: 14985366
  6. The retinoid X receptor, beta is expressed widely and can be found in almost every tissue. PMID: 15608692
  7. In the RXRB polymorphism, no genotype TT is observed in patients with psoriasis guttata with a positive personal history of repeated tonsillitis (p(corr) = 0.001). PMID: 17341859
  8. In healthy elderly men reduction of RXRbeta expression in peripheral blood mononuclear cells might be a common feature of physiological senescence. PMID: 17916375

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Subcellular Location Nucleus. Cytoplasm.
Protein Families Nuclear hormone receptor family, NR2 subfamily
Tissue Specificity Expressed in aortic endothelial cells (at protein level). Expressed in monocytes. Expressed in a variety of tumor cell lines.
Database Links

HGNC: 10478

OMIM: 180246

KEGG: hsa:6257

STRING: 9606.ENSP00000363812

UniGene: Hs.388034

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