HCRTR2 Antibody

1. The rs2653349 (G1246A) polymorphism of the HCRTR2 gene reduces the chance of developing cluster headache. PMID: 29959630
2. Association between HCRTR2, ADH4,CLOCK gene polymorphisms and cluster headache was not significant in the present study. PMID: 29318394
3. The present study demonstrated that aa residues in the C-terminus serve an important role in the expression and signal transduction of OX2R. In addition, the aa residues in different locations possess evidentially different roles. PMID: 28487995
4. This study showed that Lack of Association between Genetic Polymorphism of ox2r gene with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population PMID: 27335043
5. G-protein-dependency of OX2 receptor signalling PMID: 27237973
6. Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation is highly unlikely to be caused by mutations in the exons of the HCRTR2 gene. PMID: 26555080
7. The study determined structures of OX1R bound to the OX1R-selective antagonist SB-674042 and the dual antagonist suvorexant at 2.8-A and 2.75-A resolution and explored mechanisms of antagonist the subtype selectivity between OX1R and OX2R. PMID: 26950369
8. our meta-analysis provides genetic evidence for a role of HCRTR2 in cluster headache PMID: 25398231
9. Heart failure patients with minor allele for rs7767652, upstream of hypocretin (orexin) receptor-2 (HCRTR2), were less likely to have improved left ventricular function and a lower prevalence of ejection fraction >35% PMID: 26653627
10. the nonsynonymous rs2653349 single nucleotide polymorphism (SNP) (located on the gene that encodes orexin [hypocretin] receptor 2) was selected as the most notable SNP associated with Fagerstrom Test for Nicotine Dependence. PMID: 26289589
11. Antibodies from vaccine-associated narcolepsy sera cross-reacted with both influenza nucleoprotein and hypocretin receptor 2. PMID: 26136476
12. The genotypic and allelic frequencies of the rs2653349 polymorphism were different between Alzheimer's disease patients and controls. The carriage of the G allele was associated with an increased AD risk. PMID: 24969517
13. using lipid-mediated crystallization and protein engineering with a novel fusion chimaera, the structure of the human OX2R bound to suvorexant at 2.5 A resolution is solved PMID: 25533960
14. DQ B1 but not HLA-DR typing, TNF-alpha levers, HCRTR1 and HCRTR2 were higher in narcolepsy-cataplexy/schizophrenia patients. PMID: 24268496
15. Orexinergic innervation and expression of genes encoding OX2R receptor are upregulated in transgenic mice at dusk. PMID: 24599460
16. Expression of the OX2R protein was detected in normal endometrial epithelia, whereas it was frequently lacking in endometrial endometrioid carcinoma. PMID: 23482607
17. Data demonstrated that hOX2R expression is regulated by a complex involving a proximal PKA/PKC-regulated promoter and a distal promoter regulating tissue-specific expression of alternative transcripts which in turn regulate receptor levels. PMID: 20156195
18. The data suggest that the HCRTR2 gene or a linked locus significantly modulates the risk for cluster headache. PMID: 15477554
19. All adrenal cortex adenomas expressed OX1-R and OX2-R mRNAs, and real-time PCR showed that the expression of both receptors was up-regulated in adenomas PMID: 15797953
20. Our results do not support a role of the HCRTR2 G1246A polymorphism in drug responses in CH. PMID: 17376114
21. polymorphism of the HCRTR2 gene may modulate the genetic risk for cluster headache PMID: 17563843
22. the HCRTR2 gene is not a genetic risk factor in migraine. PMID: 17645762
23. This study does not support a major contribution of the HCRTR2 G1246A polymorphism to the pathogenesis of migraine in contrast to its effects in cluster headache. PMID: 17883525
24. Three new polymorphisms of the HCRTR2 gene are significantly associated with cluster headache. PMID: 18399985
25. This study describes the intracellular signalling pathways involved in OX2R-mediated ERK(1/2) and p38 MAPK activation. PMID: 18599270
26. Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor. PMID: 19751316

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HGNC: 4849

OMIM: 602393

KEGG: hsa:3062

STRING: 9606.ENSP00000359899

UniGene: Hs.151624