SCEL Antibody

Code CSB-PA020805GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
SCEL
Alternative Names
FLJ21667 antibody; MGC22531 antibody; Scel antibody; SCEL_HUMAN antibody; Sciellin antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Human SCEL
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.
Gene References into Functions
  1. These results demonstrate that SCEL is a mesenchymal-to-epithelial transition inducer dynamically regulated through the metastasis process PMID: 27013588
  2. Sciellin, SPRR3, and periplakin transcripts were all upregulated (4.67-, 4.95-, 2.77-fold, respectively) by prolonged exposure to cyclic strain (24-72 h), but not at earlier time points. PMID: 19211270
  3. VDUP1 and sciellin were more highly expressed in keratinocytes undergoing differentiation and colocalization of the proteins could be demonstrated PMID: 14632196
  4. Single nucleotide polymorphisms were detected in both matching tumor and normal esophageal tissues but no disease-associated mutations suggesting that SCEL is not a major factor in esophageal squamous cell carcinogenesis. PMID: 15274303
Subcellular Location
Cytoplasm. Membrane. Note=May become cross-linked to membrane proteins by transglutaminase.
Tissue Specificity
Highly expressed in esophagus. It is also expressed in keratinocytes, amniotic tissue, foreskin stratum spinosum and stratum granulosum, hair follicle and nail.
Database Links

HGNC: 10573

OMIM: 604112

KEGG: hsa:8796

STRING: 9606.ENSP00000302579

UniGene: Hs.534699

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