SCN1B Antibody, HRP conjugated

Datasheet
Code CSB-PA020835LB01HU
Size US$299
Uniprot No. Q07699
Immunogen Recombinant Human Sodium channel subunit beta-1 protein (44-156AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Sodium channel subunit beta-1, SCN1B
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Neuroscience
Target Names SCN1B
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
Involvement in disease Generalized epilepsy with febrile seizures plus 1 (GEFS+1); Brugada syndrome 5 (BRGDA5); Atrial fibrillation, familial, 13 (ATFB13); Epileptic encephalopathy, early infantile, 52 (EIEE52)
Subcellular Location Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Secreted
Protein Families Sodium channel auxiliary subunit SCN1B (TC 8.A.17) family
Tissue Specificity The overall expression of isoforms 1 and 2 is very similar. Isoform 1 is abundantly expressed in skeletal muscle, heart and brain. Isoform 2 is highly expressed in brain and skeletal muscle and present at a very low level in heart, placenta, lung, liver,
Database Links

HGNC: 10586

OMIM: 600235

KEGG: hsa:6324

STRING: 9606.ENSP00000396915

UniGene: Hs.436646

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