SCN2B Antibody

Datasheet

Code	CSB-PA020838ESR1HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA020838ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SCN2B Polyclonal antibody

Uniprot No.

O60939

Target Names

SCN2B

Alternative Names

SCN2B; UNQ326/PRO386; Sodium channel subunit beta-2

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Sodium channel subunit beta-2 protein (30-160AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier.

Gene References into Functions

Findings add to the understanding of beta2 role in Nav 1.5 trafficking and localisation, which must influence cell excitability and electrical coupling in the heart. PMID: 28597987
The authors identified a flexible loop formed by (72)Cys and (75)Cys, a unique feature among the four beta-subunit isoforms. PMID: 26894959
With increased beta-2 expression, prostate cancer cells display a trend of enhanced association with nerve axons. PMID: 24892658
SCN2B is a new candidate gene associated with Brugada syndrome. PMID: 23559163
beta2 is a PS/gamma-secretase substrate, gamma-secretase mediated cleavage of beta2-C-terminal fragment is required for cell-cell adhesion and migration of beta2-expressing cells PMID: 15833746

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Involvement in disease

Atrial fibrillation, familial, 14 (ATFB14)

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Sodium channel auxiliary subunit SCN2B (TC 8.A.17) family

Tissue Specificity

Brain specific.

Database Links

HGNC: 10589

OMIM: 601327

KEGG: hsa:6327

STRING: 9606.ENSP00000278947

UniGene: Hs.129783

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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