SCN4B Antibody, HRP conjugated

Code CSB-PA818246LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SCN4B Polyclonal antibody
Uniprot No.
Target Names
SCN4B
Alternative Names
SCN4B antibody; Sodium channel subunit beta-4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Sodium channel subunit beta-4 protein (31-162AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.
Gene References into Functions
  1. SCN4B overexpression reduces cancer cell invasiveness and tumour progression. PMID: 27917859
  2. Preserved SCN4B expression is an independent indicator of favorable recurrence-free survival in classical papillary thyroid cancer. PMID: 29723302
  3. Data suggest that extracellular domains of SCN4B directly interact with each other in parallel homodimers that involve an intermolecular disulfide bond between unpaired Cys residues (Cys58) in loop connecting strands B and C and intermolecular hydrophobic and hydrogen-bonding interactions of N-terminal segments (Ser30-Val35); SCN4B homodimers appear to play role in cell-cell adhesion. PMID: 28655765
  4. The expression of a human-specific isoform of the voltage-gated sodium channel subunit SCN4B was significantly correlated to lifetime alcohol consumption PMID: 25450227
  5. results suggest the presence of a docking site that is maintained by a cysteine bridge buried within the hydrophobic core of beta4. PMID: 24297919
  6. this is the first study to demonstrate an association of SCN4B mutations with AF, suggesting SCN4B as a novel AF susceptibility gene. PMID: 23604097
  7. SCN5A-SCN4B were found to be essential for positive selection of CD4(+) T cells. PMID: 22842345
  8. The researchers found evidence of an association between SCN4B subunit mutations and sudden infant death syndrome pathogenesis. PMID: 20226894
  9. The paroxysmal extreme pain disorder associated Nav1.7 missense mutations M1627K, T1464I and V1299F increase Navbeta4 peptide-mediated resurgent sodium currents, in contrast to the erythromelalgia associated I848T and L858H Nav1.7 missense mutations. PMID: 21115638
  10. molecular cloning and characterization of sodium channel beta4 PMID: 12930796
  11. SCN4B is a long QT syndrome susceptibility gene. PMID: 17592081
  12. Co-expression of the beta1 subunit impeded slow inactivation elicited by a 30-s depolarization, such that the voltage dependence was right shifted (depolarized) and recovery was hastened. PMID: 18941776

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Involvement in disease
Long QT syndrome 10 (LQT10); Atrial fibrillation, familial, 17 (ATFB17)
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Families
Sodium channel auxiliary subunit SCN4B (TC 8.A.17) family
Tissue Specificity
Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium.
Database Links

HGNC: 10592

OMIM: 608256

KEGG: hsa:6330

STRING: 9606.ENSP00000322460

UniGene: Hs.65239

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