SCUBE3 Antibody

Code CSB-PA020868GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
Alternative Names
CEGF3 antibody; CUB and EGF containing protein 3 antibody; CUB and EGF-like domain-containing protein 3 antibody; CUB domain and EGF like repeat containing 3 antibody; DKFZp686B09105 antibody; DKFZp686B1223 antibody; DKFZp686D20108 antibody; FLJ34743 antibody; OTTHUMP00000016250 antibody; SCUB3_HUMAN antibody; SCUBE 3 antibody; SCUBE3 antibody; Signal peptide antibody; Signal peptide CUB and EGF like domain containing protein 3 antibody; Signal peptide CUB domain EGF like 3 antibody
Raised in
Species Reactivity
Human SCUBE3
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression.
Gene References into Functions
  1. The results of this pioneering study indicate that SCUBE protein family appears to have a probable role in the pathogenesis and angiogenesis development in psoriasis and SCUBE 1 and 3 may be novel markers of angiogenesis in psoriasis. PMID: 28238185
  2. Elevated expression of SCUBE3 in osteosarcoma tissues correlated with poor prognosis of the osteosarcoma patients. PMID: 27259322
  3. Results indicated that SCUBE3 might be involved in regulating the epithelial-mesenchymal transition (EMT) and malignant progression in NSCLC. PMID: 24390364
  4. Scube3 facilitates both TGFbeta and Hh signalling within an overall role of facillating inflammatory angiogenesis. PMID: 24084593
  5. results show that SCUBE3 knockdown was associated with lower vascular permeability in the tumor and effectively inhibited the metastatic potential of non-small-cell lung carcinoma PMID: 23420440
  6. in lung cancer cells, SCUBE3 could serve as an endogenous autocrine and paracrine ligand of TGF-beta type II receptor, which could regulate TGF-beta receptor signaling and modulate EMT and cancer progression PMID: 21441952
  7. Observational study of gene-disease association. (HuGE Navigator) PMID: 20546612
  8. may act locally and/or distantly through a proteolytic mechanism, and may play an important role in bone cell biology PMID: 15234972

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Subcellular Location
Secreted. Cell surface.
Tissue Specificity
Highly expressed in osteoblasts. In normal lung, mainly expressed in bronchial epithelial cells. Tends to be up-regulated in lung cancer cells.
Database Links

HGNC: 13655

OMIM: 614708

KEGG: hsa:222663

STRING: 9606.ENSP00000274938

UniGene: Hs.12923

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