SEC31A Antibody

1. USP8 deubiquitinates Sec31A and inhibits the formation of large COPII carriers, thereby suppressing collagen IV secretion. PMID: 29604273
2. findings suggest that AnxA11 maintains architectural and functional features of the ERES by coordinating with ALG-2 to stabilize Sec31A at the ERES. PMID: 25540196
3. These results suggest that Sec31 phosphorylation by CK2 controls the duration of COPII vesicle formation, which regulates ER-to-Golgi trafficking. PMID: 23349870
4. efficient COPII-dependent secretion, notably assembly of Sec13-Sec31, is required to drive epithelial morphogenesis in both two- and three-dimensional cultures PMID: 22331354
5. SEC31A-ALK fusions are recurrent in ALK-positive large B-cell lymphomas. PMID: 21109691
6. t(4;9)(q21;p24) leads to a novel SEC31A-JAK2 fusion in Hodgkin lymphoma PMID: 21325169
7. Genomic PCR and subsequent sequencing showed that the breakpoints were located in intron 23 of SEC31L1 and intron 20 of anaplastic lymphoma kinase PMID: 16161041
8. three-dimensional reconstruction of Sec13/31 cages at 30 A resolution using cryo-electron microscopy and single particle analysis PMID: 16407955
9. In vitro GST pull down analysis demonstrated that ALG-2 and its alternatively spliced isoform interact with the COPII component Sec31A in a Ca2+-dependent manner, and a biotin-labeled ALG-2 overlay assay revealed direct binding of ALG-2 to Sec31A. PMID: 17196169
10. The Sec31 active fragment is accommodated in a binding groove supported in part by Sec23 residue Phe380. PMID: 17981133

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HGNC: 17052

OMIM: 610257

KEGG: hsa:22872

STRING: 9606.ENSP00000347329

UniGene: Hs.370024