SEMA5A Antibody, HRP conjugated

1. SEMA5A gene is associated with hippocampal volume, and their interaction is associated with reasoning ability. PMID: 24291503
2. De novo translocation t(5;22)(p15.3;q11.21) associated with a partial deletion of SEMA5A identified in a patient with ASD. PMID: 26395558
3. Our data demonstrated that elevated serum Semaphorin5A (Sema5A) in SLE patients correlated with disease activity and are involved in kidney and blood system damage; ADAM17 might be involved in the release of secreted Sema5A. PMID: 28063160
4. data demonstrated that elevated serum Semaphorin5A in systemic lupus erythematosus patients correlated with disease activity and are involved in kidney and blood system damage; ADAM17 might be involved in the release of secreted Sema5A PMID: 28063160
5. Multigenerational autosomal dominant inheritance of 5p chromosomal deletions resulting in Cri-du-Chat Syndrome with SEMA5A, CTNND2, and ICE1 deficiencies has been described. PMID: 26601658
6. The Single-Nucleotide Polymorphism (SNP) of rs7702187 within the SEMA5A gene would be a high-penetrant risk factor for PD development. PMID: 24706317
7. Using human gastric cancer cell lines, found semaphorin 5A significantly promoted invasive & metastatic abilities of gastric cancer cell in vitro. Semaphorin 5A increased expression of MMP9 by activating phosphorylated ErK1/2 in gastric cancer cell. PMID: 22821546
8. Results suggest that a bioactive, secreted form of Sema5A-ECD has an intriguing and potentially important role in its ability to enhance pancreatic tumour invasiveness, angiogenesis and micrometastases. PMID: 22782341
9. Data show that Semaphorin 5A (Sema5A) and plexin-B3 inhibit glioma cell invasion through Rac1 inactivation. PMID: 21706053
10. The downregulation of SEMA5A in tumor tissue, both at the transcriptional and translational levels, was associated with poor survival among nonsmoking women with NSCLC. PMID: 20802022
11. Data represent a novel signaling of semaphorin 5A and plexin B3 in the control of cell motility by indirect inactivation of Rac1 through RhoGDIalpha. PMID: 20696765
12. data demonstrate that the expression of SEMA5A in pancreatic cancer cells regulates tumorigenesis, growth, invasion and metastasis, and it also suggests a novel target for diagnosis and treatment of pancreatic cancer PMID: 20073063
13. Semaphorin 5a is not implicated in Parkinson's disease risk in a Chinese Han population. PMID: 19957501
14. Plexin-B3 is a functional receptor for semaphorin 5A PMID: 15218527
15. The results of this study make us suggest SEMA5A as a candidate gene in the etiology of idiopathic autism. PMID: 17028446
16. Data show that the haplotypes of SEMA5A are associated with a risk of Parkinson's disease in a Chinese Han population. PMID: 18950607
17. A virtual expression database search and RT-PCR analysis showed co-expression of SEMA5A and Plexin B3, and the interaction of SEMA5A with Plexin B3 was confirmed by co-immunoprecipitation studies. PMID: 19329067
18. expression of SEMA5A is reduced in brains from autistic patients, further implicating SEMA5A as an autism susceptibility gene PMID: 19812673

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HGNC: 10736

OMIM: 609297

KEGG: hsa:9037

STRING: 9606.ENSP00000371936

UniGene: Hs.27621