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Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation.
Gene References into Functions
Results demonstrate that in stored platelets, septine-2 and septin-6 mRNAs have miR- 223 target sites, septin-2 and septin-6 are in complex with Ago-2. The results demonstrate that like in nucleated cells, enucleated platelets also have microRNA-based mechanisms for the regulation of their septins. PMID: 29943706
SUMOylation of human septins is critical for septin filament bundling and cytokinesis. PMID: 29051266
MiR-223-3p might target gene SEPT6 and promoted the biological behavior of prostate cancer. PMID: 25519054
Septin6 and Septin7 GTP binding proteins regulate AP-3- and ESCRT-dependent multivesicular body biogenesis PMID: 25380047
The SEPT6 provides the directional guidance cues necessary for polarizing the epithelial microtubule network. PMID: 21788367
Data show that Septins of the SEPT6 group preferentially interacted with septins of the SEPT2 group, SEPT3 group and SEPT7 group. PMID: 21082023
MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia PMID: 12096348
Molecular analysis using rtPCR followed by sequencing confirmed the expression of an MLL-SEPT6 fusion transcript with a novel sequence. PMID: 16843108
septin 2, 6, and 7 complexes make up polymerized filaments PMID: 16914550
These results indicate that the host proteins hnRNP A1 and septin 6 play important roles in the replication of HCV through RNA-protein and protein-protein interactions. PMID: 17229681
crystal structures of the human SEPT2 G domain and the heterotrimeric human SEPT2-SEPT6-SEPT7 complex PMID: 17637674
Demonstrate connection between septins/SOCS7/NCK signaling and the DNA damage response. PMID: 17803907
co-expression of SEPT12 altered the filamentous structure of SEPT6 in Hela cells PMID: 18047794