SETD6 Antibody

Datasheet

Code	CSB-PA855042LA01HU
Size	US$166
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Image	IHC image of CSB-PA855042LA01HU diluted at 1:200 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SETD6 Polyclonal antibody

Uniprot No.

Q8TBK2

Target Names

SETD6

Alternative Names

SETD6 antibody; N-lysine methyltransferase SETD6 antibody; EC 2.1.1.- antibody; SET domain-containing protein 6 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human N-lysine methyltransferase SETD6 protein (1-74AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SETD6 Antibody (Product code: CSB-PA855042LA01HU) is Non-conjugated. For SETD6 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA855042LB01HU	SETD6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA855042LC01HU	SETD6 Antibody, FITC conjugated
Biotin	CSB-PA855042LD01HU	SETD6 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1). Required for the maintenance of embryonic stem cell self-renewal. Methylates PAK4.

Gene References into Functions

WDR5 was identified as a substrate of SETD6 and it was revealed that the methylation of specific lysines (K207/K325) of WDR5 was critical for maintaining global histone H3K4me3 levels and promoting breast cancer cell proliferation and migration PMID: 30226578
Findings suggest that the identified mutation impairs the normal function of SETD6, which may result in the deregulation of the different pathways in which it is involved, contributing to the increased susceptibility to cancer in this FCCTX family. PMID: 28973356
High SETD6 expression is associated with bladder cancer. PMID: 28122346
PAK4 methylation by SETD6 promotes the activation of the Wnt/beta-catenin pathway. PMID: 26841865
these findings demonstrate that SETD6 negatively regulates the Nrf2-mediated oxidative stress response through a physical and catalytically independent interaction with DJ1 at chromatin. PMID: 26780326
Several chromatin proteins that associate with SETD6 are identified and SETD6 is described as an essential factor for nuclear receptor signaling and cellular proliferation. PMID: 24751716
SETD6 monomethylates H2AZ on lysine 7. PMID: 23324626
methylation of the NF-kappaB results in repression of NF-kappaB signaling PMID: 21131967
SETD6 mono-methylate Rela on K310 and negatively regulates RelA transcription activity PMID: 21131967

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Subcellular Location

Nucleus.

Protein Families

Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SETD6 subfamily

Database Links

HGNC: 26116

OMIM: 616424

KEGG: hsa:79918

STRING: 9606.ENSP00000219315

UniGene: Hs.731691

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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