SETD6 Antibody, FITC conjugated

1. WDR5 was identified as a substrate of SETD6 and it was revealed that the methylation of specific lysines (K207/K325) of WDR5 was critical for maintaining global histone H3K4me3 levels and promoting breast cancer cell proliferation and migration PMID: 30226578
2. Findings suggest that the identified mutation impairs the normal function of SETD6, which may result in the deregulation of the different pathways in which it is involved, contributing to the increased susceptibility to cancer in this FCCTX family. PMID: 28973356
3. High SETD6 expression is associated with bladder cancer. PMID: 28122346
4. PAK4 methylation by SETD6 promotes the activation of the Wnt/beta-catenin pathway. PMID: 26841865
5. these findings demonstrate that SETD6 negatively regulates the Nrf2-mediated oxidative stress response through a physical and catalytically independent interaction with DJ1 at chromatin. PMID: 26780326
6. Several chromatin proteins that associate with SETD6 are identified and SETD6 is described as an essential factor for nuclear receptor signaling and cellular proliferation. PMID: 24751716
7. SETD6 monomethylates H2AZ on lysine 7. PMID: 23324626
8. methylation of the NF-kappaB results in repression of NF-kappaB signaling PMID: 21131967
9. SETD6 mono-methylate Rela on K310 and negatively regulates RelA transcription activity PMID: 21131967

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HGNC: 26116

OMIM: 616424

KEGG: hsa:79918

STRING: 9606.ENSP00000219315

UniGene: Hs.731691