SETD6 Antibody, Biotin conjugated

Code CSB-PA855042LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SETD6 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
SETD6 antibody; N-lysine methyltransferase SETD6 antibody; EC 2.1.1.- antibody; SET domain-containing protein 6 antibody
Raised in
Species Reactivity
Recombinant Human N-lysine methyltransferase SETD6 protein (1-74AA)
Immunogen Species
Homo sapiens (Human)
Purification Method
>95%, Protein G purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1). Required for the maintenance of embryonic stem cell self-renewal. Methylates PAK4.
Gene References into Functions
  1. WDR5 was identified as a substrate of SETD6 and it was revealed that the methylation of specific lysines (K207/K325) of WDR5 was critical for maintaining global histone H3K4me3 levels and promoting breast cancer cell proliferation and migration PMID: 30226578
  2. Findings suggest that the identified mutation impairs the normal function of SETD6, which may result in the deregulation of the different pathways in which it is involved, contributing to the increased susceptibility to cancer in this FCCTX family. PMID: 28973356
  3. High SETD6 expression is associated with bladder cancer. PMID: 28122346
  4. PAK4 methylation by SETD6 promotes the activation of the Wnt/beta-catenin pathway. PMID: 26841865
  5. these findings demonstrate that SETD6 negatively regulates the Nrf2-mediated oxidative stress response through a physical and catalytically independent interaction with DJ1 at chromatin. PMID: 26780326
  6. Several chromatin proteins that associate with SETD6 are identified and SETD6 is described as an essential factor for nuclear receptor signaling and cellular proliferation. PMID: 24751716
  7. SETD6 monomethylates H2AZ on lysine 7. PMID: 23324626
  8. methylation of the NF-kappaB results in repression of NF-kappaB signaling PMID: 21131967
  9. SETD6 mono-methylate Rela on K310 and negatively regulates RelA transcription activity PMID: 21131967

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Subcellular Location
Protein Families
Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SETD6 subfamily
Database Links

HGNC: 26116

OMIM: 616424

KEGG: hsa:79918

STRING: 9606.ENSP00000219315

UniGene: Hs.731691

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