SH3BP5 Antibody, HRP conjugated

Code CSB-PA021226LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SH3BP5 Polyclonal antibody
Uniprot No.
Target Names
SH3BP5
Alternative Names
3BP5_HUMAN antibody; OTTHUMP00000208289 antibody; OTTHUMP00000208291 antibody; OTTHUMP00000208294 antibody; SAB antibody; SH3 binding protein antibody; SH3 domain binding protein 5 (BTK associated) antibody; SH3 domain binding protein 5 antibody; SH3 domain binding protein that preferentially associates with BTK antibody; SH3 domain-binding protein 5 antibody; SH3 domain-binding protein that preferentially associates with BTK antibody; SH3 domainbinding protein 5 antibody; SH3BP 5 antibody; SH3BP-5 antibody; Sh3bp5 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human SH3 domain-binding protein 5 protein (49-455AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
Gene References into Functions
  1. SH3BP5, LMO3, and SNAP25 were expressed in diffuse large B-cell lymphoma cells and associated with clinical features. PMID: 27184832
  2. REI/SH3BP5 protein family is conserved in evolution and is a group of new guanine nucleotide exchange factors for Rab11. PMID: 26745340
  3. The interplay of p-JNK with mitochondrial Sab leads to impaired respiration, ROS production, sustained JNK activation, and apoptosis. PMID: 25666017
  4. SH3BP5 binds to JNK and directly inhibits JNK through its two putative mitogen-activated protein kinase interaction motifs (KIMs). PMID: 23861391
  5. mitochondrial protein Sab is phosphorylated by stress-activated protein kinase 3 PMID: 15158451

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Subcellular Location
Cytoplasmic vesicle membrane; Peripheral membrane protein. Mitochondrion.
Protein Families
SH3BP5 family
Tissue Specificity
Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate.
Database Links

HGNC: 10827

OMIM: 605612

KEGG: hsa:9467

STRING: 9606.ENSP00000373301

UniGene: Hs.257761

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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