SIK3 Antibody

Code CSB-PA897531ESR1HU
Size US$299 How to order?
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  • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA897531ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human thymus tissue using CSB-PA897531ESR1HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) SIK3 Polyclonal antibody
Uniprot No. Q9Y2K2
Target Names SIK3
Alternative Names SIK3 antibody; KIAA0999 antibody; QSK antibody; L19Serine/threonine-protein kinase SIK3 antibody; EC 2.7.11.1 antibody; Salt-inducible kinase 3 antibody; SIK-3 antibody; Serine/threonine-protein kinase QSK antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Serine/threonine-protein kinase SIK3 protein (60-310AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis. Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3. Prevents HDAC4 translocation to the nucleus.
Gene References into Functions
  1. role in mediating high salt and IL-17 synergy leading to breast cancer cell proliferation PMID: 28658303
  2. Results found that CpG sites of C1orf106, DMBX1, and SIK3 mediate the genetic risk of psoriasis in Chinese Han population. PMID: 27980695
  3. SIK3 is activated in human osteoarthritic cartilage. PMID: 27009967
  4. Developmental role of Sik3 in hearing and requirement for the maintenance of adult auditory function is reported. PMID: 25060954
  5. SIK3 variants were associated with hypertriglyceridemia in Mexicans. PMID: 24886709
  6. These results establish the importance of SIK3 as a mitotic regulator and underscore the potential of SIK3 as a druggable antimitotic target. PMID: 24743732
  7. cAMP-mediated regulation of SIK3 suggest that SIK3 may mediate some of the effects of this important second messenger in adipocytes PMID: 22588126
  8. Overexpression of SIK3 promotes G1/S cell cycle progression, bestows survival advantages to cancer cells for growth and correlates the clinicopathological conditions of patients with ovarian cancer. PMID: 21399663
  9. Fecal ribosomal protein L19 is a genetic prognostic factor for survival in colorectal cancer. PMID: 18266979

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Subcellular Location Cytoplasm.
Protein Families Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
Tissue Specificity Expressed in chondrocytes.
Database Links

HGNC: 29165

OMIM: 614776

KEGG: hsa:23387

STRING: 9606.ENSP00000292055

UniGene: Hs.167451

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