Recombinant Human Serine/threonine-protein kinase SIK3(SIK3) ,partial

Code CSB-YP897531HU
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Source Yeast
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Code CSB-EP897531HU
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Source E.coli
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Code CSB-EP897531HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP897531HU
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Source Baculovirus
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Code CSB-MP897531HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names SIK3
Uniprot No. Q9Y2K2
Alternative Names SIK3; KIAA0999; QSK; L19Serine/threonine-protein kinase SIK3; EC 2.7.11.1; Salt-inducible kinase 3; SIK-3; Serine/threonine-protein kinase QSK
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Gene References into Functions
  1. role in mediating high salt and IL-17 synergy leading to breast cancer cell proliferation PMID: 28658303
  2. Results found that CpG sites of C1orf106, DMBX1, and SIK3 mediate the genetic risk of psoriasis in Chinese Han population. PMID: 27980695
  3. SIK3 is activated in human osteoarthritic cartilage. PMID: 27009967
  4. Developmental role of Sik3 in hearing and requirement for the maintenance of adult auditory function is reported. PMID: 25060954
  5. SIK3 variants were associated with hypertriglyceridemia in Mexicans. PMID: 24886709
  6. These results establish the importance of SIK3 as a mitotic regulator and underscore the potential of SIK3 as a druggable antimitotic target. PMID: 24743732
  7. cAMP-mediated regulation of SIK3 suggest that SIK3 may mediate some of the effects of this important second messenger in adipocytes PMID: 22588126
  8. Overexpression of SIK3 promotes G1/S cell cycle progression, bestows survival advantages to cancer cells for growth and correlates the clinicopathological conditions of patients with ovarian cancer. PMID: 21399663
  9. Fecal ribosomal protein L19 is a genetic prognostic factor for survival in colorectal cancer. PMID: 18266979

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Subcellular Location Cytoplasm
Protein Families Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
Database Links

HGNC: 29165

OMIM: 614776

KEGG: hsa:23387

STRING: 9606.ENSP00000292055

UniGene: Hs.167451

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