SLC16A11 Antibody, FITC conjugated

Code CSB-PA843323LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SLC16A11 Polyclonal antibody
Uniprot No.
Target Names
SLC16A11
Alternative Names
FLJ90193 antibody; MCT 11 antibody; Monocarboxylate transporter 11 antibody; MOT11_HUMAN antibody; SLC16A11 antibody; Solute carrier family 16 member 11 (monocarboxylic acid transporter 11) antibody; Solute carrier family 16 member 11 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Monocarboxylate transporter 11 protein (428-471AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane. Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids.
Gene References into Functions
  1. rs13342232 might be involved in the risk of pediatric-onset type 2 diabetes in Mexican families PMID: 28101933
  2. Study demonstrates that disruption of SLC16A11 in primary human hepatocytes leads to Type 2 diabetes (T2D)-relevant changes in fatty acid and lipid metabolism; these results implicate reduced SLC16A11 function in liver as a causal factor for T2D. PMID: 28666119
  3. Our study identified an association between the SLC16A11 variant rs75493593 and type 2 diabetes in American Indians, where the effect on diabetes was much more pronounced in nonobese individuals. rs75493593 was also associated with RNASEK gene expression. PMID: 26487785
  4. Genetic association studies show that common variants in ABCA1 and SLC16A11 are involved in type 2 diabetes (T2D) susceptibility. Particularly, the variants rs10811661 (CDKN2A/2B) and rs9282541 (ABCA1) are associated with T2D in adult Maya population. PMID: 25839936
  5. Despite type 2 diabetes having been well studied by GWAS in other populations, analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism. PMID: 24390345

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Involvement in disease
Diabetes mellitus, non-insulin-dependent (NIDDM)
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein Families
Major facilitator superfamily, Monocarboxylate porter (TC 2.A.1.13) family
Tissue Specificity
Expressed in liver, salivary gland and thyroid.
Database Links

HGNC: 23093

OMIM: 125853

KEGG: hsa:162515

STRING: 9606.ENSP00000310490

UniGene: Hs.336564

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