SLC17A3 Antibody

Datasheet

Code	CSB-PA021419LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA021419LA01HU at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA021419LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SLC17A3 Polyclonal antibody

Uniprot No.

O00476

Target Names

SLC17A3

Alternative Names

SLC17A3 antibody; NPT4 antibody; Sodium-dependent phosphate transport protein 4 antibody; Na(+)/PI cotransporter 4 antibody; Sodium/phosphate cotransporter 4 antibody; Solute carrier family 17 member 3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Sodium-dependent phosphate transport protein 4 protein (1-125AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SLC17A3 Antibody (Product code: CSB-PA021419LA01HU) is Non-conjugated. For SLC17A3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA021419LB01HU	SLC17A3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA021419LC01HU	SLC17A3 Antibody, FITC conjugated
Biotin	CSB-PA021419LD01HU	SLC17A3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport.

Gene References into Functions

Study used rs548987 of SLC17A3 as a candidate variant of ischemic stroke and performed association analysis in a Chinese population; although rs548987 failed to show significant association with total ischemic stroke and large vessel disease subtype, the C allele of rs548987 showed significant association with small vessel disease subtype of ischemic stroke (OR=0.68, p=0.004). PMID: 27772792
hNPT4 (SLC17A3) mediated time- and concentration-dependent uptake of OTxA (K(m): 802.8 microM) in a pH- and voltage-sensitive manner. PMID: 21778665
variants carrying SNP V257F, G279R, or P378L exhibited reduced transport of para-aminohippurate, bumetanide, estrone and urate; SNPs may contribute to inter-individual differences in disposition of anionic drugs and certain endogenous organic anions PMID: 21282933
Genetic variants within SLC2A9,ABCG2 and SLC17A3 are associated with uric acid levels PMID: 20053405
a model of urate secretion in the renal tubular cell, where intracellular urate taken up via OAT1 and/or OAT3 from the blood exits from the cell into the lumen via hNPT4. PMID: 20810651
SLC17A3 seems to have a major role in determination of serum uric acid repeated measurements variation. PMID: 20162743
mutation reduces the phosphate transport efficiency, possibly modulating the G6-Pase complex PMID: 15505377

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Subcellular Location

[Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein.; [Isoform 2]: Cell membrane; Multi-pass membrane protein.

Protein Families

Major facilitator superfamily, Sodium/anion cotransporter family

Tissue Specificity

Expressed in the liver and kidney. It is detected in proximal tubules in renal cortex as well as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level).

Database Links

HGNC: 10931

OMIM: 611034

KEGG: hsa:10786

STRING: 9606.ENSP00000380250

UniGene: Hs.327179

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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