SLC22A17 Antibody, FITC conjugated

Datasheet

Code	CSB-PA823881LC01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SLC22A17 Polyclonal antibody

Uniprot No.

Q8WUG5

Target Names

SLC22A17

Alternative Names

24p3 receptor antibody; 24p3R antibody; BOCT antibody; BOIT antibody; Brain type organic cation transporter antibody; Brain-type organic cation transporter antibody; hBOIT antibody; Lipocalin-2 receptor antibody; Neutrophil gelatinase associated lipocalin receptor antibody; Neutrophil gelatinase-associated lipocalin receptor antibody; NGAL receptor antibody; NgalR antibody; NGALR2 antibody; NGALR3 antibody; OTTHUMP00000082690 antibody; OTTHUMP00000082691 antibody; Potent brain type organic ion transporter antibody; S22AH_HUMAN antibody; Slc22a17 antibody; Solute carrier family 22 member 17 antibody; Solute carrier family 22 organic cation transporter member 17 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Solute carrier family 22 member 17 protein (1-99AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.

Gene References into Functions

Results showed the expression levels of NGAL and NGALR significantly downregulated in clear cell renal cell carcinoma samples. PMID: 30138675
Biochemical and Structural Characterization of the Interaction between the Siderocalin NGAL/LCN2 (Neutrophil Gelatinase-associated Lipocalin/Lipocalin 2) and the N-terminal Domain of Its Endocytic Receptor SLC22A17. PMID: 26635366
Lipocalin 2 might restore the health and regeneration potential of MSCs by decreasing senescence PMID: 24452457
No significant difference was found in the expressions of NGALR mRNA in placenta among moderate preeclampsia group, severe preeclampsia group and control group. PMID: 22932106
NGAL and NGALR expression might be served as novel prognostic factors and potential therapeutic targets in Hepatocellular carcinoma. PMID: 22728279
This study suggested that NGAL and NGALR expression are frequently up-regulated in gliomas, and are closely associated with poor clinical outcome. PMID: 21184133
These results suggested that SLC22A17, in cooperation with LCN2, to be involved in the acquisition of aggressive behavior among endometrial carcinoma cells. PMID: 21763306
Neutrophil gelatinase-associated lipocalin receptor (NGALR) is differentially expressed in human glomerular disease and is significantly up-regulated by Il-1beta in HMC via MAPK/ERK activation. PMID: 21305251
NGALR hypomethylation contributes to its expression in esophageal carcinomas and that this overexpression may play a role in the pathogenesis of esophageal carcinomas. PMID: 19047093

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Note=Upon LCN2-binding, it is internalized.

Protein Families

Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family

Tissue Specificity

Expressed in brain.

Database Links

HGNC: 23095

OMIM: 611461

KEGG: hsa:51310

STRING: 9606.ENSP00000206544

UniGene: Hs.373498

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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