SLC23A1 Antibody

1. consensus site for HNF1 that is crucial for the regulation of the human SVCT1 promoter is present in the SVCT1 rat promoter but has no effect on its transcriptional activity PMID: 25933589
2. SNP rs6596473 of SLC23A1 is suggested to be associated with AgP. results add to previous reports vitamin C plays a role in pathogenesis of periodontitis. PMID: 24708273
3. Data from observational/genetic association studies in Europe suggest an SNP in SLC23A1 (rs33972313) is associated with up-regulation of circulating L-ascorbic acid but not with any cardiometabolic/cardiovascular outcome investigated. [META-ANALYSIS] PMID: 25527764
4. The SVCT1 was induced and localized to the apical membrane of tubular epithelial cells. PMID: 22990596
5. A genetic variant in the SLC23A1 ascorbate transporter locus was identified and is associated with an increased risk of Crohn disease in a white Canadian inflammatory bowel diseases cohort. PMID: 24284447
6. SVCT1 directly interacts with GRHPR. PMID: 23599041
7. These findings show a role for Rab8a in the physiological function of SVCT1 in intestinal epithelia. PMID: 23014846
8. A genetic variant (rs33972313) in the SLC23A1 vitamin C active transporter locus was identified that is reliably associated with circulating concentrations of L-ascorbic acid in the general population. PMID: 20519558
9. Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 20519558
10. SVCT1 is the transporter that allows vectorial uptake of ascorbic acid in differentiated CaCo-2 cells PMID: 12381735
11. Results provide the first direct resolution of functional hSVCT1 expression at the apical cell surface of polarized epithelia and define an apical targeting signal of relevance to transporters of diverse substrate specificity. PMID: 15084584
12. Findings link genetic variants in the vitamin C transporter gene SLC23A1 to spontaneous preterm birth. PMID: 16357110
13. C uptake is increased in UVB-irradiated keratinocytes through the translocation of SVCT-1 and regulates inflammatory response in the skin via the downregulation of IL-8 and MCP-1 production PMID: 17008880
14. We present a transport model for SVCT1 that will provide a framework for investigating the impact of specific mutations and polymorphisms in SLC23A1 and help us better understand the contribution of SVCT1 to vitamin C metabolism in health and disease. PMID: 18094143
15. The results suggest that uncharged His51 of hSVCT1, directly or indirectly, contributes to substrate binding through the hydrogen bond. PMID: 18247577
16. SVCT1 may be targeted to facilitate the delivery of drugs with low bioavailability by conjugating with ascorbic acid PMID: 18417304
17. N-Glycosylation is therefore essential for SVCT1 functionality. PMID: 18619416
18. The analysis of common single nucleotide polymorphisms in SLC23A1 revealed no association with colorectal adenoma risk. PMID: 18791929
19. Results using short interfering RNA suggest that in HepG2 cells, decreasing hSVCT2 message levels reduces the overall ascorbic acid uptake process more than decreasing hSVCT1 message levels. PMID: 18845575
20. Results describe the membrane topology of human SVCT1 and SVCT2, and the role of glycosylation on protein transport. PMID: 19379732
21. HNF-1alpha and/or HNF-1beta binding is required for SVCT1 expression PMID: 19741195
22. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 18818748

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HGNC: 10974

OMIM: 603790

KEGG: hsa:9963

STRING: 9606.ENSP00000302851

UniGene: Hs.643467