SLC24A1 Antibody

Code CSB-PA070252
Size US$100
Order now
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Uniprot No.
Target Names
SLC24A1
Alternative Names
CSNB1D antibody; HsT17412 antibody; KIAA0702 antibody; Na(+)/K(+)/Ca(2+) exchange protein 1 antibody; Na(+)/K(+)/Ca(2+)-exchange protein 1 antibody; NCKX antibody; NCKX1 antibody; NCKX1_HUMAN antibody; Retinal rod Na Ca+K exchanger antibody; Retinal rod Na+/Ca+/K+ exchanger antibody; Retinal rod Na-Ca+K exchanger antibody; RODX antibody; Slc24a1 antibody; Sodium/potassium/calcium exchanger 1 antibody; Solute carrier family 24 (sodium/potassium/calcium exchanger) member 1 antibody; Solute carrier family 24 member 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human NCKX1.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).
Gene References into Functions
  1. We report the association of many previously unreported variants with retinal disease, as well as new disease phenotypes associated with known genes, including the first association of the SLC24A1 gene with retinitis pigmentosa PMID: 27624628
  2. The index patient and his affected brother carry a homozygous single-nucleotide variants (SNVs) in sodium-calcium, potassium exchanger (SLC24A1) (c.2401G > T). PMID: 26822852
  3. A mutation in SLC24A1 is implicated in autosomal-recessive congenital stationary night blindness. PMID: 20850105
Involvement in disease
Night blindness, congenital stationary, 1D (CSNB1D)
Subcellular Location
Membrane; Multi-pass membrane protein.
Protein Families
Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC24A subfamily
Tissue Specificity
Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer.
Database Links

HGNC: 10975

OMIM: 603617

KEGG: hsa:9187

STRING: 9606.ENSP00000261892

UniGene: Hs.173092

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*