SLC24A1 Antibody

Datasheet

Code	CSB-PA021469ESR1HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA021469ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SLC24A1 Polyclonal antibody

Uniprot No.

O60721

Target Names

SLC24A1

Alternative Names

CSNB1D antibody; HsT17412 antibody; KIAA0702 antibody; Na(+)/K(+)/Ca(2+) exchange protein 1 antibody; Na(+)/K(+)/Ca(2+)-exchange protein 1 antibody; NCKX antibody; NCKX1 antibody; NCKX1_HUMAN antibody; Retinal rod Na Ca+K exchanger antibody; Retinal rod Na+/Ca+/K+ exchanger antibody; Retinal rod Na-Ca+K exchanger antibody; RODX antibody; Slc24a1 antibody; Sodium/potassium/calcium exchanger 1 antibody; Solute carrier family 24 (sodium/potassium/calcium exchanger) member 1 antibody; Solute carrier family 24 member 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Sodium/potassium/calcium exchanger 1 protein (330-452AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).

Gene References into Functions

We report the association of many previously unreported variants with retinal disease, as well as new disease phenotypes associated with known genes, including the first association of the SLC24A1 gene with retinitis pigmentosa PMID: 27624628
The index patient and his affected brother carry a homozygous single-nucleotide variants (SNVs) in sodium-calcium, potassium exchanger (SLC24A1) (c.2401G > T). PMID: 26822852
A mutation in SLC24A1 is implicated in autosomal-recessive congenital stationary night blindness. PMID: 20850105

Involvement in disease

Night blindness, congenital stationary, 1D (CSNB1D)

Subcellular Location

Membrane; Multi-pass membrane protein.

Protein Families

Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC24A subfamily

Tissue Specificity

Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer.

Database Links

HGNC: 10975

OMIM: 603617

KEGG: hsa:9187

STRING: 9606.ENSP00000261892

UniGene: Hs.173092

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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