SLC24A4 Antibody

Code CSB-PA129178
Size US$297
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  • Western blot analysis of extracts from RAW264.7 cells, using SLC24A4 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SLC24A4 Polyclonal antibody
Uniprot No.
Target Names
SLC24A4
Alternative Names
Na(+)/K(+)/Ca(2+)-exchange protein 4 antibody; NCKX4 antibody; NCKX4_HUMAN antibody; SHEP6 antibody; SLC24A2 antibody; SLC24A4 antibody; Sodium/potassium/calcium exchanger 4 antibody; Solute carrier family 24 (sodium/potassium/calcium exchanger) member 4 antibody; Solute carrier family 24 member 4 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from internal of Human SLC24A4.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis.
Gene References into Functions
  1. no significant relation was noted between SLC24A4 rs10498633 and late-onset Alzheimer;s disease risk in neither apolipoprotein E (APOE) epsilon4 carriers nor non-carriers after adjusting for age and gender PMID: 27215332
  2. pigment cells express robust, functional NCKX4 activity PMID: 27093457
  3. mutations in SLC24A4 and SLC24A5 are responsible for the phenotypic defects observed in human amylogenesis imperfecta and non-syndromic oculocutaneous albinism patients. PMID: 27129268
  4. The expressions of NCX1 and NCKX4 were significantly higher in the patent ductus arteriosus group at both the protein and mRNA levels. PMID: 25500693
  5. enamel maturation is dependent upon STIM1 and SLC24A4 function, and that there are important differences in the Ca(2+) transcellular transport systems used by secretory- and maturation-stage ameloblasts. PMID: 24621671
  6. Brain DNA methylation in sLC24A4 was associated with pathological Alzheimer disease. PMID: 25365775
  7. These findings support a key role for SLC24A4 in calcium transport during enamel formation. PMID: 23375655
  8. Taken together, these data demonstrate a potentially important role for NCX1 in control of Ca2+ homeostasis and link store depletion via STIM1 directly with NCX activation. PMID: 21126331
  9. identification and sequencing, as well as mapping to chromosomal region 14q32 PMID: 12379639
  10. IRF4 and SLC24A4 loci are associated with human hair color and skin pigmentation. PMID: 18483556

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Involvement in disease
Amelogenesis imperfecta, hypomaturation type, 2A5 (AI2A5)
Subcellular Location
Cytoplasm. Cell membrane; Multi-pass membrane protein.
Protein Families
Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC24A subfamily
Tissue Specificity
Expressed abundantly in all regions of the brain, aorta, lung and thymus. Expressed at lower levels in the stomach and intestine.
Database Links

HGNC: 10978

OMIM: 210750

KEGG: hsa:123041

STRING: 9606.ENSP00000431840

UniGene: Hs.385530

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