SLC27A1 Antibody, FITC conjugated

Datasheet
Code CSB-PA740768LC01HU
Size US$299
Uniprot No. Q6PCB7
Protocols ELISA Protocol
Immunogen Recombinant Human Long-chain fatty acid transport protein 1 protein (453-570AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity).
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Long-chain fatty acid transport protein 1 (FATP-1) (Fatty acid transport protein 1) (EC 6.2.1.-) (Solute carrier family 27 member 1), SLC27A1, ACSVL5 FATP1
Immunogen Species Homo sapiens (Human)
Research Area Signal Transduction
Target Names SLC27A1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity).
Subcellular Location Cell membrane, Single-pass membrane protein, Endomembrane system, Single-pass membrane protein, Cytoplasm
Protein Families ATP-dependent AMP-binding enzyme family
Tissue Specificity Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver.
Database Links

HGNC: 10995

OMIM: 600691

KEGG: hsa:376497

STRING: 9606.ENSP00000252595

UniGene: Hs.363138

Pathway PPAR signaling pathway
Myocardial Fatty Acid Metabolism

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