SLC27A1 Antibody, HRP conjugated

Datasheet

Code	CSB-PA740768LB01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SLC27A1 Polyclonal antibody

Uniprot No.

Q6PCB7

Target Names

SLC27A1

Alternative Names

SLC27A1 antibody; ACSVL5 antibody; FATP1Long-chain fatty acid transport protein 1 antibody; FATP-1 antibody; Fatty acid transport protein 1 antibody; EC 6.2.1.- antibody; Solute carrier family 27 member 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Long-chain fatty acid transport protein 1 protein (453-570AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Mediates the ATP-dependent import of long-chain fatty acids (LCFA) into the cell by mediating their translocation at the plasma membrane. Has also an acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Probably involved in fatty acid transport across the blood barrier.

Gene References into Functions

Neonatal phthalate ester exposure induced placental MTs, FATP1 and HFABP mRNA expression PMID: 26867681
Several proteins that are expressed in the epidermis have been proposed to facilitate the uptake of long-chain fatty acids (LCFA) in mammalian cells, CD36, fatty acid binding protein, and FATP. [review] PMID: 24120574
Observational study of gene-disease association. (HuGE Navigator) PMID: 20965718
Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and lecithin:retinol acyltransferase PMID: 20356843
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20416077
exogenously supplied fatty acids are preferentially channeled by an FATP1-linked mechanism into the TG biosynthetic pathway; such internalized lipids downregulate de novo sphingomyelin and cholesterol metabolism in growing 293 cells PMID: 12235169
FATP1 might play a role in post-prandial lipid metabolism and development of cardiovascular disease. PMID: 12818409
FATP1 stimulated transport and consumption of palmitate and oleate, which they channeled away from complete oxidation and toward TAG synthesis. PMID: 15897321
These data reveals the localization and points to a regulatory function of FATP1 in myotube mitochondria. PMID: 19361580
Observational study of gene-disease association. (HuGE Navigator) PMID: 18660489
Observational study of gene-disease association. (HuGE Navigator) PMID: 12818409
Observational study of gene-disease association. (HuGE Navigator) PMID: 15978856

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Subcellular Location

Cell membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein. Cytoplasm.

Protein Families

ATP-dependent AMP-binding enzyme family

Tissue Specificity

Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver. Expressed in brain gray matter.

Database Links

HGNC: 10995

OMIM: 600691

KEGG: hsa:376497

STRING: 9606.ENSP00000252595

UniGene: Hs.363138

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

PPAR signaling pathway Myocardial Fatty Acid Metabolism

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