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Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
Gene References into Functions
means of immunolabeled cells for GLUT-3 varied approximately from 19% to 73% PMID: 30049187
PPAR-gamma and Akt regulate GLUT1 and GLUT3 surface localization during Mycobacterium tuberculosis infection PMID: 28852964
miR-29c was down-regulated in Prostate cancer samples. SLC2A3, a regulator of glycolysis, was validated as a direct target of miR-29c. Moreover, functional studies showed miR-29c could inhibit cell growth, induce apoptosis and deceased the rate of glucose metabolism. PMID: 29715514
Both common and rare SLC2A3 variation impacting regulation of neuronal glucose utilization and energy homeostasis may result in neurocognitive deficits known to contribute to ADHD risk. PMID: 28224622
identify a subset of tumors within the "proneural" and "classical" subtypes that are addicted to aberrant signaling from integrin alphavbeta3, which activates a PAK4-YAP/TAZ signaling axis to enhance Glut3 expression PMID: 29198914
GLUT3-mediated glucose utilization and glycogenolysis in platelets promotes alpha-granule release, platelet activation, and postactivation functions. PMID: 28663252
effects of physiologically relevant phospholipids on glucose transport in liposomes containing purified GLUT4 and GLUT3. The anionic phospholipids, phosphatidic acid, phosphatidylserine, phosphatidylglycerol, and phosphatidylinositol, were found to be essential for transporter function by activating it and stabilizing its structure. PMID: 27302065
High Glut3 expression is associated with gastric cancer. PMID: 26643879
GLUT3 and OCT4 expression were correlated suggesting that Human embryonic stem cells self-renewal is regulated by the rate of glucose uptake. PMID: 26639784
Using lipidic cubic phase crystallization and microfocus X-ray diffraction, we determined the structure of human GLUT3 in complex with D-glucose at 1.5 A resolution in an outward-occluded conformation PMID: 26176916
We observed a strong relationship between characteristics of adaptive change to hypoxia, GLUT3 expression among birth weight-discordant twin PMID: 25728965
The SLC2A3 duplication was the most frequent CNV detected and the only significant finding in our combined analysis , indicating that the SLC2A3 duplication might serve as a genetic modifier of congenital heart defect PMID: 25892112
Glut3 is a downstream target of mTORC1, and it is critical for oncogenic mTORC1-mediated aerobic glycolysis and tumorigenesis. PMID: 25578782
Data from human genetic analysis, molecular biology and a Drosophila Huntington's disease (HD) model strongly support the hypothesis that increased dosage of SLC2A3 ameliorates HD phenotypes. PMID: 24452335
Patients after coronary artery bypass graft surgery, who have low GLUT3 levels are at increased risk for new-onset postoperative atrial fibrillation. PMID: 24463787
deletions and single-nucleotide variations involving the GLUT3 gene that may be associated with increased susceptibility to myelomeningocele (MM). PMID: 24813597
study presents discovery and characterization of a large copy-number variant (CNV) within the chr12p13.31 interval; genotyping of this CNV in multiple population samples produced evidence that a deletion spanning the SLC2A3 gene confers substantial protection against rheumatoid arthritis PMID: 24178905
Decreased miR-106a in GBM tissues and conferred a poor survival of GBM patients. SLC2A3 was identified as a core target of miR-106a in GBM cells. PMID: 24124917
Data suggest that expression of GLUT3/SLC2A3 (but not GLUT1 or GLUT4) is up-regulated in placenta in pregnancies complicated by intrauterine growth restriction (with expression of GLUT3 in cytotrophoblasts greater than in syncytiotrophoblasts). PMID: 24011442
sensitive and specific marker for embryonal carcinomas and yolk sac tumors PMID: 23343953
Nutrient restriction contributes to tumor progression by enriching for brain tumor initiating cells (BTICs); BTICs outcompete for glucose uptake by co-opting the high affinity neuronal glucose transporter, type 3 (Glut3, SLC2A3). PMID: 23995067
GLUT3 shows increasing promoter methylation across gestation. PMID: 22901689
The level of GLUT3 is correlated with the level of full-length CREB in Alzheimer brain samples. PMID: 23341039
hypoxia-induced increases in glucose uptake through GLUT3 are important for lipid synthesis in macrophages, and may contribute to foam cell formation in hypoxic regions of atherosclerotic lesions. PMID: 22876317
Data show that elevated CAV1 upregulates glucose uptake and ATP production through HMGA1-mediated GLUT3 transcription, suggesting that CAV1 may render tumor cells growth advantages by enhancing aerobic glycolysis. PMID: 22706202
We clarified that early hypoxia-responsive genes are functionally associated with glycolysis, including SLC2A3. PMID: 22645302
High GLUT3 is associated with endometrial and breast cancers. PMID: 22270867
miR-195-5p is a novel and also the first identified miRNA that targets GLUT3, and the aberrant decreased expression of miR-195-5p and consequent GLUT3 up-regulation may contribute to bladder carcinogenesis. PMID: 22265971
GLUT3 is present in the syncytial microvillous membrane early in gestation and decreases thereafter, supporting the idea that GLUT3 is of greater importance for glucose uptake early in gestation. PMID: 22000473
Human glucose transporter type 3 (GLUT3)in the brain exhibits water channel properties PMID: 22113212
Results suggest a possible transregulation effect on SLC2A3, which might lead to glucose deficits in dyslexic children and could explain their attenuated mismatch negativity in passive listening tasks. PMID: 19786962
DNA-damaging agents reduce GLUT3 expression in cancer cells through activation of the MEK-ERK pathway independently of p53, leading to cell death or apoptosis PMID: 20870738
In pluripotent stem cells and in human cancer disease, podocalyxin may function in part to regulate and maintain the cell surface expression of the glucose-3-transporter. PMID: 20599725
expression of HIF-1alpha and GLUT-3 in glioma was correlated significantly with tumors' pathological grade, which can be taken as a pair of useful markers for predicting the biological behavior of glioma PMID: 19782666
GLUT3 is expressed by normal articular chondrocytes. PMID: 11991658
Restricted to regenerating muscle fibres and nerves in adult human muscle. GLUT3 may be important for glucose supply in fetal muscle fibres and regenerating adult muscle fibres. PMID: 12397394
Embedded in microvillous (maternal-facing) and basal (fetal-facing) membranes of syncytiotrophoblast, main placental barrier layer. (review) PMID: 12583599
in platelets glucose transport through GLUT3 is regulated by changes in surface expression and affinity modulation, which are both under control of PKB PMID: 16049004
Regulation of GLUT3 and glucose uptake by the cAMP signallling pathway in the breast cancer cell line ZR-75 is reported. PMID: 17559076
IGF-1 plays a role in maintaining muscle GLUT3 expression and basal glucose uptake via the transcriptional factor Sp1. PMID: 17920708
GLUT3 expression was studied in normal and degenerate intervertebral discs. PMID: 18172662
In hyperthyroidism: 1) basal abundance of GLUT3 and GLUT4 on the plasma membrane is increased and 2) the sensitivity of the recruitment of GLUT3 and GLUT4 transporters on the plasma membrane in response to IGF-I is increased PMID: 18299470
GLUT-3 gene expression level was high in head and neck carcinoma (HNCs), and its expression was associated with an increased incidence of lymph node metastasis of HNCs. PMID: 18401196
differential expression of Glut-3 by benign and malignant melanocytic lesions PMID: 18764953
Sertoli cells express GLUT1 and GLUT3 throughout pubertal development. PMID: 18802725
the activation of AMP-activated protein kinase and its regulation of cell surface GLUT3 expression is critical in mediating neuronal tolerance to excitotoxicity PMID: 19261894
The expression pattern of GLUT3 is reported in newly diagnosed esophageal adenocarcinoma by means of immunohistochemistry. PMID: 19554504
The neuronal glucose transporter 3 was decreased to a bigger extent in Type 2 Diabetes Mellitus brain than in Alzheimer's disease brain. PMID: 19659459