SLC30A6 Antibody

Datasheet

Code	CSB-PA744010LA01HU
Size	US$166
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Image	Western blot All lanes: SLC30A6 antibody at 6µg/ml Lane 1: A549 whole cell lysate Lane 2: U251 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 52, 56, 48, 49 kDa Observed band size: 52 kDa Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA744010LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA744010LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA744010LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SLC30A6 Polyclonal antibody

Uniprot No.

Q6NXT4

Target Names

SLC30A6

Alternative Names

SLC30A6; ZNT6; Zinc transporter 6; ZnT-6; Solute carrier family 30 member 6

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Zinc transporter 6 protein (246-461AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SLC30A6 Antibody (Product code: CSB-PA744010LA01HU) is Non-conjugated. For SLC30A6 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA744010LB01HU	SLC30A6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA744010LC01HU	SLC30A6 Antibody, FITC conjugated
Biotin	CSB-PA744010LD01HU	SLC30A6 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment.

Gene References into Functions

There was a significant increase in protein levels of ZnT6 in the prefrontal cortex in Major depression disorder, relative to control subjects. PMID: 27661418
A genetic variant within SLC30A6 has a protective role in the severity of Rheumatoid Arthritis. PMID: 27758124
results of this study suggested that ZnT6 protein levels are decreased in the spinal cords of sporadic ALS patients. PMID: 25284286
The results of this study showed that signi fi cant positive correlations between ZIP1,ZnT1, and ZnT6 in most brain in patient with Alzheimer's disease. PMID: 22349685
our results suggest that alterations in Zn transport proteins ZnT-1, ZnT-4 and ZnT-6 may contribute to the pathology observed in preclinical Alzheimer's disease subjects before onset of clinical symptoms PMID: 19371353
Our results show that Zn transporter-4 and Zn transporter-6 are significantly (P<0.05) increased in hippocampus/parahippocampal gyrus of early Alzheimer's disease and Alzheimer's disease subjects. PMID: 16580781
hZnT-6 is up-regulated in response to cellular zinc depletion in Raji & THP-1 cells. PMID: 17971500
Data show that ZNT6 is extensively present in the Abeta-positive plaques in the cortex of human AD brains. PMID: 18639746
The cytosolic C-terminal tail of ZnT5 is important for its interaction with ZnT6 as a heterodimer. PMID: 19759014

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Subcellular Location

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.

Protein Families

Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family, SLC30A subfamily

Tissue Specificity

Expressed in brain; especially in cerebellum, hippocampus, parahippocampal gyrus, superior and middle temporal gyrus. Also expressed in B-cells, colon, eye, and lung. Lower expression was present in bone, brain, cervix, ear, heart, kidney, muscle, nerve,

Database Links

HGNC: 19305

OMIM: 611148

KEGG: hsa:55676

UniGene: Hs.23248

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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