SLC30A6 Antibody, FITC conjugated

Code CSB-PA744010LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SLC30A6 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
SLC30A6; ZNT6; Zinc transporter 6; ZnT-6; Solute carrier family 30 member 6
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Zinc transporter 6 protein (246-461AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment.
Gene References into Functions
  1. There was a significant increase in protein levels of ZnT6 in the prefrontal cortex in Major depression disorder, relative to control subjects. PMID: 27661418
  2. A genetic variant within SLC30A6 has a protective role in the severity of Rheumatoid Arthritis. PMID: 27758124
  3. results of this study suggested that ZnT6 protein levels are decreased in the spinal cords of sporadic ALS patients. PMID: 25284286
  4. The results of this study showed that signi fi cant positive correlations between ZIP1,ZnT1, and ZnT6 in most brain in patient with Alzheimer's disease. PMID: 22349685
  5. our results suggest that alterations in Zn transport proteins ZnT-1, ZnT-4 and ZnT-6 may contribute to the pathology observed in preclinical Alzheimer's disease subjects before onset of clinical symptoms PMID: 19371353
  6. Our results show that Zn transporter-4 and Zn transporter-6 are significantly (P<0.05) increased in hippocampus/parahippocampal gyrus of early Alzheimer's disease and Alzheimer's disease subjects. PMID: 16580781
  7. hZnT-6 is up-regulated in response to cellular zinc depletion in Raji & THP-1 cells. PMID: 17971500
  8. Data show that ZNT6 is extensively present in the Abeta-positive plaques in the cortex of human AD brains. PMID: 18639746
  9. The cytosolic C-terminal tail of ZnT5 is important for its interaction with ZnT6 as a heterodimer. PMID: 19759014

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Subcellular Location
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.
Protein Families
Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family, SLC30A subfamily
Tissue Specificity
Expressed in brain; especially in cerebellum, hippocampus, parahippocampal gyrus, superior and middle temporal gyrus. Also expressed in B-cells, colon, eye, and lung. Lower expression was present in bone, brain, cervix, ear, heart, kidney, muscle, nerve,
Database Links

HGNC: 19305

OMIM: 611148

KEGG: hsa:55676

UniGene: Hs.23248

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