SLC4A10/SLC4A8 Antibody

Code CSB-PA859849
Size US$297
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  • Western blot analysis of extracts from COLO cells, using SLC4A8/10 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SLC4A10/SLC4A8 Polyclonal antibody
Uniprot No.
Target Names
SLC4A10/SLC4A8
Alternative Names
NBCn 2 antibody; NBCn2 antibody; NCBE antibody; S4A10 antibody; S4A10_HUMAN antibody; SLC 4A10 antibody; SLC4 A10 antibody; SLC4A 10 antibody; Slc4a10 antibody; Sodium driven chloride bicarbonate exchanger antibody; Sodium-driven chloride bicarbonate exchanger antibody; Solute carrier family 4 member 10 antibody; Solute carrier family 4, sodium bicarbonate cotransporter like, member 10 antibody; Solute carrier family 4, sodium bicarbonate transporter like, member 10 antibody; Solute carrier family 4, sodium bicarbonate transporter, member 10 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from internal of Human SLC4A8/10.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH. Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride. Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange. Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid. Reduces the excitability of CA1 pyramidal neurons and modulates short-term synaptic plasticity. Required in retinal cells to maintain normal pH which is necessary for normal vision. In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules.
Gene References into Functions
  1. genetic variation in SLC4A10 expression and function in the central nervous system may affect the regulation of systemic water balance PMID: 28360221
  2. There was no association between common sequence variants in the AQP1 or SLC4A10 genes and primary open-angle glaucoma in the Caucasian population. PMID: 20101282
  3. propose to rename NCBE as the second electroneutral Na/HCO(3) cotransporter, NBCn2 PMID: 18319254
  4. SLC4A10 (OMIM 605556), a sodium bicarbonate transporter gene with high expression in the cerebral cortex and hippocampus, was disrupted by the translocation breakpoint on chromosome 2q24. PMID: 18413482
Subcellular Location
Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon. Perikaryon. Cell junction, synapse, presynapse. Cell junction, synapse, postsynapse.
Protein Families
Anion exchanger (TC 2.A.31) family
Tissue Specificity
Predominantly expressed in the brain.
Database Links

HGNC: 13811

OMIM: 605556

KEGG: hsa:57282

STRING: 9606.ENSP00000393066

UniGene: Hs.333958

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