SLC7A6 Antibody, FITC conjugated

Code CSB-PA849761LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SLC7A6 Polyclonal antibody
Uniprot No.
Target Names
SLC7A6
Alternative Names
SLC7A6 antibody; KIAA0245 antibody; Y+L amino acid transporter 2 antibody; Cationic amino acid transporter antibody; y+ system antibody; Solute carrier family 7 member 6 antibody; y(+)L-type amino acid transporter 2 antibody; Y+LAT2 antibody; y+LAT-2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Y+L amino acid transporter 2 protein (473-515AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells.
Gene References into Functions
  1. Results suggest that leukemia cell proliferation can be significantly suppressed by blocking amino acid transporter LAT3. PMID: 24142711
  2. Inhibition of LAT transporters may provide a novel therapeutic target in metastatic castration-resistant prostate cancer, via suppression of mammalian target of rapamycin complex 1 activity and M-phase cell cycle genes. PMID: 24052624
  3. LAT3 may play a crucial role in the development and maintenance of podocyte structure and function by regulating protein synthesis and the actin cytoskeleton. PMID: 19443642
Subcellular Location
Basolateral cell membrane; Multi-pass membrane protein.
Protein Families
Amino acid-polyamine-organocation (APC) superfamily, L-type amino acid transporter (LAT) (TC 2.A.3.8) family
Tissue Specificity
Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, RPE cells, and various carcinoma cell lines.
Database Links

HGNC: 11064

OMIM: 605641

KEGG: hsa:9057

STRING: 9606.ENSP00000219343

UniGene: Hs.679580

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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