Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SLCO1C1 Polyclonal antibody

Uniprot No.

Q9NYB5

Target Names

SLCO1C1

Alternative Names

OAT-RP-5 antibody; OATP-14 antibody; OATP-F antibody; OATP1 antibody; OATP1C1 antibody; OATPRP5 antibody; Organic anion transporter F antibody; Organic anion transporter polypeptide-related protein 5 antibody; organic anion transporting polypeptide 14 antibody; Organic anion-transporting polypeptide 14 antibody; SLC21A14 antibody; Slco1c1 antibody; SO1C1_HUMAN antibody; solute carrier family 21 (organic anion transporter), member 14 antibody; Solute carrier family 21 member 14 antibody; Solute carrier organic anion transporter family member 1C1 antibody; solute carrier organic anion transporter family, member 1C1 antibody; Thyroxine transporter antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Solute carrier organic anion transporter family member 1C1 protein (297-348AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a significant role in regulating T4 flux into and out of the brain.

Gene References into Functions

The genetic variant, rs3794271, located within the PDE3A-SLCO1C1 locus was analyzed for correlation with treatment response using both the EULAR classification criteria and absolute change in (Delta)DAS28 scores as outcome measures correlated with anti-TNF response in a large UK rheumatoid arthritis cohort. PMID: 27180831
We found a highly significant association between PDE3A-SLCO1C1 and the clinical response to TNF blockers PMID: 25403996
The PDE3A-SLCO1C1 locus rs3794271 SNP showed a highly significant association with anti-TNF treatment response. PMID: 23651021
Compared with the adult cerebral cortex, mRNAs encoding OATP1A2, OATP1C1, OATP3A1 variant 2, OATP4A1, LAT2 and CD98 were reduced in fetal cortex at different gestational ages, whilst mRNAs encoding MCT8, MCT10, OATP3A1 variant 1 and LAT1 were similar. PMID: 21486766
The strong expression of MCT10 and OATP1C1 in the human hypothalamus indicates a possible role in the regulation of the hypothalamus-pituitary-thyroid axis. PMID: 21508134
We have isolated and functionally characterized OATP-F. OATP-F has a more selective substrate preference and may play an important role in the disposition of thyroid hormones in brain and testis. PMID: 12351693
OATP1C1 polymorphisms are associated with fatigue and depression, but do not explain differences in neurocognitive functioning or appreciation of LT4-LT3 combination therapy. PMID: 18410547
OATP1C1 mediates transport of thyroid hormones and increases the access of these substrates to the intracellular active sites of the deiodinases with no effect of genetic variation PMID: 18566113
OATP14 mRNA and protein are strongly enriched in mouse and rat cerebral microvessels but not in human microvessels. PMID: 18687783
Protein is highly expressed in the intestine, kidney, cholangiocytes and the blood-brain barrier. PMID: 19290786
Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18410547

Hide All

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

Organo anion transporter (TC 2.A.60) family

Tissue Specificity

Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels.

Database Links

HGNC: 13819

OMIM: 613389

KEGG: hsa:53919

STRING: 9606.ENSP00000370964

UniGene: Hs.47261

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：
If CAPTCHA verification fails, click to refresh the CAPTCHA and try again.

Code	CSB-PA868355LD01HU
Size	US$166
	Order now
Have Questions?	Leave a Message or Start an on-line Chat

SLCO1C1 Antibody, Biotin conjugated

Product Details

Related Products

Customer Reviews and Q&A

Target Background