SLK Antibody

Datasheet

Code	CSB-PA867135ESR2HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA867135ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SLK Polyclonal antibody

Uniprot No.

Q9H2G2

Target Names

SLK

Alternative Names

SLK antibody; KIAA0204 antibody; STK2 antibody; STE20-like serine/threonine-protein kinase antibody; STE20-like kinase antibody; hSLK antibody; EC 2.7.11.1 antibody; CTCL tumor antigen se20-9 antibody; STE20-related serine/threonine-protein kinase antibody; STE20-related kinase antibody; Serine/threonine-protein kinase 2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human STE20-like serine/threonine-protein kinase protein (1-230AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Mediates apoptosis and actin stress fiber dissolution.

Gene References into Functions

SLK interacts with Tpr and alpha-actinin-4 in cells, and these protein-protein interactions may control the subcellular localization and the biological activity of SLK. PMID: 26094769
SLK activated ERMs, together with Galphai, are critical for the correct localization of LGN-NuMA force generator complexes and hence for proper spindle orientation. PMID: 24958772
The fact that SLK (LOSK) phosphorylates only a minor isoform 1A of p150(Glued) suggests that transport and microtubule-organizing functions of dynactin are distinctly divided between the two isoforms PMID: 23985322
v-Src-dependent down-regulation of the Ste20-like kinase SLK through casein kinase II. PMID: 16837460
we show that a novel isoform of SPS1-related proline alanine-rich kinase (SPAK/STE20) is involved in this inflammatory signaling cascade PMID: 17321610
Protein kinase LOSK is required for radial microtubule organization and for the proper localization of Golgi complex in various cell types. PMID: 18287541
Studies define an interaction between Neu and SLK signaling in the regulation of cancer cell motility. PMID: 19525980

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Subcellular Location

Cytoplasm.

Protein Families

Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily

Tissue Specificity

Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle.

Database Links

HGNC: 11088

OMIM: 616563

KEGG: hsa:9748

STRING: 9606.ENSP00000358770

UniGene: Hs.591922

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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