SLK Antibody

Code CSB-PA021776GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
SLK
Alternative Names
SLK antibody; KIAA0204 antibody; STK2 antibody; STE20-like serine/threonine-protein kinase antibody; STE20-like kinase antibody; hSLK antibody; EC 2.7.11.1 antibody; CTCL tumor antigen se20-9 antibody; STE20-related serine/threonine-protein kinase antibody; STE20-related kinase antibody; Serine/threonine-protein kinase 2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Human SLK
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Mediates apoptosis and actin stress fiber dissolution.
Gene References into Functions
  1. SLK interacts with Tpr and alpha-actinin-4 in cells, and these protein-protein interactions may control the subcellular localization and the biological activity of SLK. PMID: 26094769
  2. SLK activated ERMs, together with Galphai, are critical for the correct localization of LGN-NuMA force generator complexes and hence for proper spindle orientation. PMID: 24958772
  3. The fact that SLK (LOSK) phosphorylates only a minor isoform 1A of p150(Glued) suggests that transport and microtubule-organizing functions of dynactin are distinctly divided between the two isoforms PMID: 23985322
  4. v-Src-dependent down-regulation of the Ste20-like kinase SLK through casein kinase II. PMID: 16837460
  5. we show that a novel isoform of SPS1-related proline alanine-rich kinase (SPAK/STE20) is involved in this inflammatory signaling cascade PMID: 17321610
  6. Protein kinase LOSK is required for radial microtubule organization and for the proper localization of Golgi complex in various cell types. PMID: 18287541
  7. Studies define an interaction between Neu and SLK signaling in the regulation of cancer cell motility. PMID: 19525980

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Subcellular Location
Cytoplasm.
Protein Families
Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
Tissue Specificity
Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle.
Database Links

HGNC: 11088

OMIM: 616563

KEGG: hsa:9748

STRING: 9606.ENSP00000358770

UniGene: Hs.591922

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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