SLK Antibody

Code CSB-PA923093
Size US$297
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  • Western blot analysis of extract from MCF-7 cells using SLK1 Antibody
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SLK Polyclonal antibody
Uniprot No.
Target Names
SLK
Alternative Names
SLK antibody; KIAA0204 antibody; STK2 antibody; STE20-like serine/threonine-protein kinase antibody; STE20-like kinase antibody; hSLK antibody; EC 2.7.11.1 antibody; CTCL tumor antigen se20-9 antibody; STE20-related serine/threonine-protein kinase antibody; STE20-related kinase antibody; Serine/threonine-protein kinase 2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Peptide sequence around aa.1187~1191(K-T-L-E-E) derived from Human SLK1.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:1000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Mediates apoptosis and actin stress fiber dissolution.
Gene References into Functions
  1. SLK interacts with Tpr and alpha-actinin-4 in cells, and these protein-protein interactions may control the subcellular localization and the biological activity of SLK. PMID: 26094769
  2. SLK activated ERMs, together with Galphai, are critical for the correct localization of LGN-NuMA force generator complexes and hence for proper spindle orientation. PMID: 24958772
  3. The fact that SLK (LOSK) phosphorylates only a minor isoform 1A of p150(Glued) suggests that transport and microtubule-organizing functions of dynactin are distinctly divided between the two isoforms PMID: 23985322
  4. v-Src-dependent down-regulation of the Ste20-like kinase SLK through casein kinase II. PMID: 16837460
  5. we show that a novel isoform of SPS1-related proline alanine-rich kinase (SPAK/STE20) is involved in this inflammatory signaling cascade PMID: 17321610
  6. Protein kinase LOSK is required for radial microtubule organization and for the proper localization of Golgi complex in various cell types. PMID: 18287541
  7. Studies define an interaction between Neu and SLK signaling in the regulation of cancer cell motility. PMID: 19525980

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Subcellular Location
Cytoplasm.
Protein Families
Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
Tissue Specificity
Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle.
Database Links

HGNC: 11088

OMIM: 616563

KEGG: hsa:9748

STRING: 9606.ENSP00000358770

UniGene: Hs.591922

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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