Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SMARCD3 Polyclonal antibody

Uniprot No.

Q6STE5

Target Names

SMARCD3

Alternative Names

60 kDa BRG 1/Brm associated factor subunit C antibody; 60 kDa BRG-1/Brm-associated factor subunit C antibody; BAF60C antibody; BRG1 associated factor 60C antibody; BRG1-associated factor 60C antibody; Chromatin remodeling complex BAF60C subunit antibody; CRACD3 antibody; Mammalian chromatin remodeling complex BRG1 associated factor 60C antibody; MGC111010 antibody; Rsc6p antibody; Smarcd3 antibody; SMRD3_HUMAN antibody; SWI/SNF complex 60 kDa subunit C antibody; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily d member 3 antibody; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3, isoform 1 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 antibody; Swp73 like protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 protein (2-101AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

Gene References into Functions

Data show that the combination of GATA binding protein 4 (Gata4), T-box transcription factor 5 (Tbx5) and BRG1-associated factor 60C protein (Baf60c) is sufficient for inducing adipose tissue-derived mesenchymal stem cells (ADMSCs) to form cardiomyocytes. PMID: 26071180
Inhibition of Wnt5a by either RNAi knockdown or blocking antibody reversed Smarcd3 -induced epithelial-mesenchymal transition. Thus, Smarcd3 epigenetically regulates epithelial-mesenchymal transition by activating WNT signaling pathways. PMID: 23716599
Deptor is induced by the Baf60c-Six4 transcriptional complex and mediates activation of Akt and glycolytic metabolism by Baf60c in a cell-autonomous manner PMID: 23563706
BAF60c promotes lipogenesis in vivo and increases triglyceride levels, demonstrating its role in metabolic adaption to activate the lipogenic program in response to feeding and insulin. PMID: 23219531
Data show a combination of only five genes (-BCL6, T (BRACHYURY), c-MYC, MITF and BAF60C (SMARCD3) rapidly and efficiently convert postnatal chorion and decidual cells into chondrocytes. PMID: 22833560
BAF60c phosphorylation on a conserved threonine is the signal that promotes incorporation of MyoD-BAF60c into a Brg1-based SWI/SNF complex, which remodels the chromatin & activates transcription of MyoD-target genes. PMID: 22068056
GTNB directs cardiogenesis from human embryonic stem cells and induces correct cardiac development. PMID: 21694703
BAF60c represents a new coregulator that constitutes an important anchoring point by which the SWI/SNF complex is recruited to nuclear receptors and other transcription factors PMID: 14701856
Tat-mediated activation of the HIV promoter requires the SWI/SNF complex in synergy with the coactivator p300. PMID: 16687403
Baf60c is re-expressed in the Muller glial cells that re-enter the cell cycle after neurotoxic damage PMID: 18816825

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Subcellular Location

Nucleus.

Protein Families

SMARCD family

Tissue Specificity

Isoform 2 and isoform 1 are expressed in brain, heart, kidney, placenta, prostate, salivary gland, spleen, testis, thyroid, trachea and uterus. Isoform 1 is also expressed in skeletal muscle and adipose tissue.

Database Links

HGNC: 11108

OMIM: 601737

KEGG: hsa:6604

STRING: 9606.ENSP00000262188

UniGene: Hs.647067