SMARCE1 Antibody

Code CSB-PA839275LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA839275LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SMARCE1 Polyclonal antibody
Uniprot No.
Target Names
SMARCE1
Alternative Names
BAF57 antibody; BRG1 associated factor 57 antibody; BRG1-associated factor 57 antibody; Chromatin remodeling complex BRG1 associated factor 57 antibody; FLJ35648 antibody; SMARCE 1 antibody; SMARCE1 antibody; SMCE1_HUMAN antibody; SWI/SNF related matrix associated actin dependent regulator of chromatin e1 antibody; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily e member 1 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 protein (20-243AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SMARCE1 Antibody (Product code: CSB-PA839275LA01HU) is Non-conjugated. For SMARCE1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA839275LB01HU SMARCE1 Antibody, HRP conjugated ELISA
FITC CSB-PA839275LC01HU SMARCE1 Antibody, FITC conjugated
Biotin CSB-PA839275LD01HU SMARCE1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells.
Gene References into Functions
  1. High SMARCE1 expression is associated with eventual relapse and metastasis in breast cancer. PMID: 28377514
  2. miR-29a promotes hepatitis B virus (HBV) replication and expression through regulating SMARCE1 in HBV-infected HepG2.2.15 cells. PMID: 28740345
  3. We report here three additional individuals with clinical features consistent with CSS and alterations in SMARCE1, one of which is novel. The probands all exhibited dysmorphic facial features, moderate developmental and cognitive delay, poor growth, and hypoplastic digital nails/phalanges, including digits not typically affected in the other genes associated with CSS. PMID: 27264197
  4. SMARCE1 mutational hits, including novel SMARCE1 mutations, were found in six of eight tested patients with clear cell meningioma PMID: 27891692
  5. An exhaustive analysis of the BAF57 molecular and biochemical properties, cellular functions, loss-of-function phenotypes in living organisms and pathological manifestations in cases of human mutations. [review] PMID: 27149204
  6. a family with a pediatric CCM patient and an adult CCM patient and several asymptomatic relatives carrying a germline SMARCE1 mutation. PMID: 26803492
  7. Addition of the EGFR inhibitor gefitinib restores the sensitivity of SMARCE1-knockdown cells to MET and ALK inhibitors in NSCLCs. Our findings link SMARCE1 to EGFR oncogenic signaling and suggest targeted treatment options for SMARCE1-deficient tumors. PMID: 25656847
  8. The results suggested that BAF57 is involved in ovarian cancer cell growth and sensitivity to anticancer agents, and that BAF57 may be a target for ovarian cancer therapy. PMID: 25611552
  9. BAF complex gene SMARCE1 is mutated in Coffin-Siris syndrome patients. PMID: 25081545
  10. Genotype-phenotype correlation of Coffin-Siris syndrome caused by mutations in SmarCE1 gene. PMID: 25168959
  11. Since both TTF1 and SMARCE1 are involved in chromatin remodeling, our results imply an epigenetic regulatory mechanism for T-cell recruitment that invites deciphering. PMID: 24880093
  12. these results demonstrate that loss of SMARCE1 is relevant to cranial as well as spinal meningiomas PMID: 25143307
  13. Data indicate that BAF57 deregulation predisposes to metastasis. PMID: 23493350
  14. Our findings identify multiple-spinal-meningioma disease as a new discrete entity and establish a key role for the SWI/SNF complex in the pathogenesis of both meningiomas and tumors with clear-cell histology. PMID: 23377182
  15. mutations in BAF57 could impinge on several oncogenic signaling pathways contributing to the origin and/or development of breast cancer. PMID: 21465167
  16. BAF57 expression was significantly associated with the surgical stage, grade of the tumor, myometrial invasion, lympho-vascular space invasion and lymph node metastasis in 111 endometrial carcinomas. PMID: 22419023
  17. Knockdown of BAF57 resulted in an accumulation of cells in the G(2)-M phase, inhibition of colony formation, and impaired growth in soft agar. Knockdown of BAF57 also caused transcriptional misregulation of various cell cycle-related gene. PMID: 20460533
  18. BAF57-mediated cell death is associated with up-regulation of proapoptotic genes including the tumor suppressor familial cylindromatosis (CYLD), which is found to be a direct target of BAF57. PMID: 16135788
  19. BAF57 is a critical regulator of estrogen receptor function in breast cancer cells PMID: 16769725
  20. Ability of SMARCE 1 in modulating the replication efficiency of HBV. PMID: 17669635

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Involvement in disease
Meningioma (MNGMA); Coffin-Siris syndrome 5 (CSS5)
Subcellular Location
Nucleus.
Database Links

HGNC: 11109

OMIM: 603111

KEGG: hsa:6605

STRING: 9606.ENSP00000323967

UniGene: Hs.743978

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