Recombinant Human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1)

1. High SMARCE1 expression is associated with eventual relapse and metastasis in breast cancer. PMID: 28377514
2. miR-29a promotes hepatitis B virus (HBV) replication and expression through regulating SMARCE1 in HBV-infected HepG2.2.15 cells. PMID: 28740345
3. We report here three additional individuals with clinical features consistent with CSS and alterations in SMARCE1, one of which is novel. The probands all exhibited dysmorphic facial features, moderate developmental and cognitive delay, poor growth, and hypoplastic digital nails/phalanges, including digits not typically affected in the other genes associated with CSS. PMID: 27264197
4. SMARCE1 mutational hits, including novel SMARCE1 mutations, were found in six of eight tested patients with clear cell meningioma PMID: 27891692
5. An exhaustive analysis of the BAF57 molecular and biochemical properties, cellular functions, loss-of-function phenotypes in living organisms and pathological manifestations in cases of human mutations. [review] PMID: 27149204
6. a family with a pediatric CCM patient and an adult CCM patient and several asymptomatic relatives carrying a germline SMARCE1 mutation. PMID: 26803492
7. Addition of the EGFR inhibitor gefitinib restores the sensitivity of SMARCE1-knockdown cells to MET and ALK inhibitors in NSCLCs. Our findings link SMARCE1 to EGFR oncogenic signaling and suggest targeted treatment options for SMARCE1-deficient tumors. PMID: 25656847
8. The results suggested that BAF57 is involved in ovarian cancer cell growth and sensitivity to anticancer agents, and that BAF57 may be a target for ovarian cancer therapy. PMID: 25611552
9. BAF complex gene SMARCE1 is mutated in Coffin-Siris syndrome patients. PMID: 25081545
10. Genotype-phenotype correlation of Coffin-Siris syndrome caused by mutations in SmarCE1 gene. PMID: 25168959
11. Since both TTF1 and SMARCE1 are involved in chromatin remodeling, our results imply an epigenetic regulatory mechanism for T-cell recruitment that invites deciphering. PMID: 24880093
12. these results demonstrate that loss of SMARCE1 is relevant to cranial as well as spinal meningiomas PMID: 25143307
13. Data indicate that BAF57 deregulation predisposes to metastasis. PMID: 23493350
14. Our findings identify multiple-spinal-meningioma disease as a new discrete entity and establish a key role for the SWI/SNF complex in the pathogenesis of both meningiomas and tumors with clear-cell histology. PMID: 23377182
15. mutations in BAF57 could impinge on several oncogenic signaling pathways contributing to the origin and/or development of breast cancer. PMID: 21465167
16. BAF57 expression was significantly associated with the surgical stage, grade of the tumor, myometrial invasion, lympho-vascular space invasion and lymph node metastasis in 111 endometrial carcinomas. PMID: 22419023
17. Knockdown of BAF57 resulted in an accumulation of cells in the G(2)-M phase, inhibition of colony formation, and impaired growth in soft agar. Knockdown of BAF57 also caused transcriptional misregulation of various cell cycle-related gene. PMID: 20460533
18. BAF57-mediated cell death is associated with up-regulation of proapoptotic genes including the tumor suppressor familial cylindromatosis (CYLD), which is found to be a direct target of BAF57. PMID: 16135788
19. BAF57 is a critical regulator of estrogen receptor function in breast cancer cells PMID: 16769725
20. Ability of SMARCE 1 in modulating the replication efficiency of HBV. PMID: 17669635

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HGNC: 11109

OMIM: 603111

KEGG: hsa:6605

STRING: 9606.ENSP00000323967

UniGene: Hs.743978