SMIM1 Antibody

Datasheet

Code	CSB-PA450720LA01HU
Size	US$166
Image	Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA450720LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA450720LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
Citations
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SMIM1 Polyclonal antibody

Uniprot No.

B2RUZ4

Target Names

SMIM1

Alternative Names

Small integral membrane protein 1 antibody; SMIM1 antibody; SMIM1_HUMAN antibody; Vel blood group antigen antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Small integral membrane protein 1 protein (1-46AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SMIM1 Antibody (Product code: CSB-PA450720LA01HU) is Non-conjugated. For SMIM1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA450720LB01HU	SMIM1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA450720LC01HU	SMIM1 Antibody, FITC conjugated
Biotin	CSB-PA450720LD01HU	SMIM1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

Proteome expression profiling of red blood cells during the tumorigenesis of hepatocellular carcinoma S Wang,Plos one,2022
Proteome Expression Profile for Red Blood Cells Enables Diagnostics for Hepatocellular Carcinoma S Wang,Research Square,2021

Customer Reviews and Q&A

■ Customer Reviews

Average Rating:

5.0 - 2 reviews

Submit a Review here

Applications : Immunohistochemical staining

Sample type: Cells

Review: Analysis for SMIM1 and ANXA7 expression in a cohort of LC, HCC and HC, respectively. The protein expression was calculated from mass spectrometry data and the signifi cant difference analysis were conducted between groups; E- F, The expression trend of SMIM1 and ANXA7 during the tumorigenesis were verifi ed with PRM strategy with another batch of clinical samples from LC (N=9), HCC (N=11) and HC (N=10); G. Immunostaining for SMIM1 in normal liver and HCC tissue.

By Anonymous

Applications : Immunohistochemistry

Sample type: cells

Review: Alterations in RBCs and potential biomarker identification during tumorigenesis of LC to HCC. Immunostaining of SMIM1 in normal liver and HCC tissue. Immunostaining of SMIM1 in normal liver and HCC tissue.

By Anonymous

Target Background

Function

Regulator of red blood cell formation.

Gene References into Functions

rs1175550G and to a lesser extent rs143702418C independently increase SMIM1 and Vel antigen expression. PMID: 28084402
Among the 448 samples analysed, 10 (2.23%) harboured the 17 bp deletion of the gene SMIM1, and all were heterozygote for the SMIM1*64_80 del allele. PMID: 27328373
Alleles that initially entered the population have been maintained within the population. The c.64_80del null allele of SMIM1 is one such allele, thus having implications for transfusion medicine and child or maternal health. PMID: 26666208
SMIM1 carries the Vel antigen as a type II membrane protein with a predicted C-terminal extracellular domain of only 3-12 amino acids PMID: 26452714
Weak Vel expression levels are caused by multiple genetic factors in SMIM1 and probably also by other genetic or environmental factors. PMID: 25647324
A cohort of 70 Vel- individuals was found to be uniformly homozygous for a 17 nucleotide deletion in the coding sequence of SMIM1. PMID: 23505126
Loss of SMIM1 is associated with reduction in red blood cell formation. PMID: 23563606
Loss of SMIM1 is associated with reduction in red blood cell formation. PMID: 23563608

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Subcellular Location

Cell membrane; Single-pass type II membrane protein.

Protein Families

SMIM1 family

Tissue Specificity

Highly expressed in the bone marrow and expressed at lower levels in non-hematopoietic tissues. Highly expressed in erythroleukemia cell lines. Up-regulated in CD34+ hematopoietic progenitors cultured toward red blood cells.

Database Links

HGNC: 44204

OMIM: 615242

KEGG: hsa:388588

STRING: 9606.ENSP00000457386

UniGene: Hs.22047

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA

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SMIM1 Antibody

Product Details

Citations

Related Products

Customer Reviews and Q&A

Target Background