SMIM1 Antibody

Code CSB-PA450720LA01HU
Size US$299
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  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA450720LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA450720LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) SMIM1 Polyclonal antibody
Uniprot No. B2RUZ4
Target Names SMIM1
Alternative Names Small integral membrane protein 1 antibody; SMIM1 antibody; SMIM1_HUMAN antibody; Vel blood group antigen antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Small integral membrane protein 1 protein (1-46AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated

The SMIM1 Antibody (Product code: CSB-PA450720LA01HU) is Non-conjugated. For SMIM1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA450720LB01HU SMIM1 Antibody, HRP conjugated ELISA
FITC CSB-PA450720LC01HU SMIM1 Antibody, FITC conjugated
Biotin CSB-PA450720LD01HU SMIM1 Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Applications : Immunohistochemical staining

Sample type: Cells

Review: Analysis for SMIM1 and ANXA7 expression in a cohort of LC, HCC and HC, respectively. The protein expression was calculated from mass spectrometry data and the signifi cant difference analysis were conducted between groups; E- F, The expression trend of SMIM1 and ANXA7 during the tumorigenesis were verifi ed with PRM strategy with another batch of clinical samples from LC (N=9), HCC (N=11) and HC (N=10); G. Immunostaining for SMIM1 in normal liver and HCC tissue.

By Anonymous

Applications : Immunohistochemistry

Sample type: cells

Review: Alterations in RBCs and potential biomarker identification during tumorigenesis of LC to HCC. Immunostaining of SMIM1 in normal liver and HCC tissue. Immunostaining of SMIM1 in normal liver and HCC tissue.

By Anonymous

Target Background

Function
Regulator of red blood cell formation.
Gene References into Functions
  1. rs1175550G and to a lesser extent rs143702418C independently increase SMIM1 and Vel antigen expression. PMID: 28084402
  2. Among the 448 samples analysed, 10 (2.23%) harboured the 17 bp deletion of the gene SMIM1, and all were heterozygote for the SMIM1*64_80 del allele. PMID: 27328373
  3. Alleles that initially entered the population have been maintained within the population. The c.64_80del null allele of SMIM1 is one such allele, thus having implications for transfusion medicine and child or maternal health. PMID: 26666208
  4. SMIM1 carries the Vel antigen as a type II membrane protein with a predicted C-terminal extracellular domain of only 3-12 amino acids PMID: 26452714
  5. Weak Vel expression levels are caused by multiple genetic factors in SMIM1 and probably also by other genetic or environmental factors. PMID: 25647324
  6. A cohort of 70 Vel- individuals was found to be uniformly homozygous for a 17 nucleotide deletion in the coding sequence of SMIM1. PMID: 23505126
  7. Loss of SMIM1 is associated with reduction in red blood cell formation. PMID: 23563606
  8. Loss of SMIM1 is associated with reduction in red blood cell formation. PMID: 23563608

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Subcellular Location Cell membrane; Single-pass type II membrane protein.
Protein Families SMIM1 family
Tissue Specificity Highly expressed in the bone marrow and expressed at lower levels in non-hematopoietic tissues. Highly expressed in erythroleukemia cell lines. Up-regulated in CD34+ hematopoietic progenitors cultured toward red blood cells.
Database Links

HGNC: 44204

OMIM: 615242

KEGG: hsa:388588

STRING: 9606.ENSP00000457386

UniGene: Hs.22047

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