SMIM1 Antibody, Biotin conjugated

Code CSB-PA450720LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SMIM1 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Small integral membrane protein 1 antibody; SMIM1 antibody; SMIM1_HUMAN antibody; Vel blood group antigen antibody
Raised in
Species Reactivity
Recombinant Human Small integral membrane protein 1 protein (1-46AA)
Immunogen Species
Homo sapiens (Human)
Purification Method
>95%, Protein G purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Regulator of red blood cell formation.
Gene References into Functions
  1. rs1175550G and to a lesser extent rs143702418C independently increase SMIM1 and Vel antigen expression. PMID: 28084402
  2. Among the 448 samples analysed, 10 (2.23%) harboured the 17 bp deletion of the gene SMIM1, and all were heterozygote for the SMIM1*64_80 del allele. PMID: 27328373
  3. Alleles that initially entered the population have been maintained within the population. The c.64_80del null allele of SMIM1 is one such allele, thus having implications for transfusion medicine and child or maternal health. PMID: 26666208
  4. SMIM1 carries the Vel antigen as a type II membrane protein with a predicted C-terminal extracellular domain of only 3-12 amino acids PMID: 26452714
  5. Weak Vel expression levels are caused by multiple genetic factors in SMIM1 and probably also by other genetic or environmental factors. PMID: 25647324
  6. A cohort of 70 Vel- individuals was found to be uniformly homozygous for a 17 nucleotide deletion in the coding sequence of SMIM1. PMID: 23505126
  7. Loss of SMIM1 is associated with reduction in red blood cell formation. PMID: 23563606
  8. Loss of SMIM1 is associated with reduction in red blood cell formation. PMID: 23563608

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Subcellular Location
Cell membrane; Single-pass type II membrane protein.
Protein Families
SMIM1 family
Tissue Specificity
Highly expressed in the bone marrow and expressed at lower levels in non-hematopoietic tissues. Highly expressed in erythroleukemia cell lines. Up-regulated in CD34+ hematopoietic progenitors cultured toward red blood cells.
Database Links

HGNC: 44204

OMIM: 615242

KEGG: hsa:388588

STRING: 9606.ENSP00000457386

UniGene: Hs.22047

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