Name: SMIM1 Antibody, FITC conjugated
Brand: CUSABIO
SKU: CSB-PA450720LC01HU

Product Details

Full Product Name	Rabbit anti-Homo sapiens (Human) SMIM1 Polyclonal antibody
Uniprot No.	B2RUZ4
Target Names	SMIM1
Alternative Names	Small integral membrane protein 1 antibody; SMIM1 antibody; SMIM1_HUMAN antibody; Vel blood group antigen antibody
Raised in	Rabbit
Species Reactivity	Human
Immunogen	Recombinant Human Small integral membrane protein 1 protein (1-46AA)
Immunogen Species	Homo sapiens (Human)
Conjugate	FITC
Clonality	Polyclonal
Isotype	IgG
Purification Method	>95%, Protein G purified
Concentration	It differs from different batches. Please contact us to confirm it.
Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form	Liquid
Troubleshooting and FAQs	Antibody FAQs
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time	Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function	Regulator of red blood cell formation.
Gene References into Functions	rs1175550G and to a lesser extent rs143702418C independently increase SMIM1 and Vel antigen expression. PMID: 28084402 Among the 448 samples analysed, 10 (2.23%) harboured the 17 bp deletion of the gene SMIM1, and all were heterozygote for the SMIM1*64_80 del allele. PMID: 27328373 Alleles that initially entered the population have been maintained within the population. The c.64_80del null allele of SMIM1 is one such allele, thus having implications for transfusion medicine and child or maternal health. PMID: 26666208 SMIM1 carries the Vel antigen as a type II membrane protein with a predicted C-terminal extracellular domain of only 3-12 amino acids PMID: 26452714 Weak Vel expression levels are caused by multiple genetic factors in SMIM1 and probably also by other genetic or environmental factors. PMID: 25647324 A cohort of 70 Vel- individuals was found to be uniformly homozygous for a 17 nucleotide deletion in the coding sequence of SMIM1. PMID: 23505126 Loss of SMIM1 is associated with reduction in red blood cell formation. PMID: 23563606 Loss of SMIM1 is associated with reduction in red blood cell formation. PMID: 23563608 Show More Hide All
Subcellular Location	Cell membrane; Single-pass type II membrane protein.
Protein Families	SMIM1 family
Tissue Specificity	Highly expressed in the bone marrow and expressed at lower levels in non-hematopoietic tissues. Highly expressed in erythroleukemia cell lines. Up-regulated in CD34+ hematopoietic progenitors cultured toward red blood cells.
Database Links	HGNC: 44204 OMIM: 615242 KEGG: hsa:388588 STRING: 9606.ENSP00000457386 UniGene: Hs.22047

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SMIM1 Antibody, FITC conjugated

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Code	CSB-PA450720LC01HU
Size	US$299
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