SMYD1 Antibody

Datasheet

Code	CSB-PA847673ESR1HU
Size	US$166
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Image	Western blot All lanes: Histone-lysine N-methyltransferase SMYD1 antibody at 2μg/ml Lane 1: Mouse heart tissue Lane 2: 293T whole cell lysate Lane 3: Mouse skeletal muscle tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 57 kDa Observed band size: 57 kDa Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA847673ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA847673ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SMYD1 Polyclonal antibody

Uniprot No.

Q8NB12

Target Names

SMYD1

Alternative Names

BOP antibody; CD8 beta opposite antibody; CD8b opposite antibody; Histone lysine N methyltransferase SMYD1 antibody; KMT3D antibody; SET and MYND domain containing 1 antibody; SET and MYND domain-containing protein 1 antibody; SMYD1 antibody; SMYD1_HUMAN antibody; Zinc finger MYND domain containing 18 antibody; ZMYND18 antibody; ZMYND22 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Histone-lysine N-methyltransferase SMYD1 protein (1-350AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.

Gene References into Functions

We present genetic and statistical evidence that the R320Q substitution in SMYD1 underlies an inherited form of the AnWj-negative blood group phenotype. The mechanism by which the mutation leads to this phenotype remains to be determined. PMID: 29956848
SMYD1 serves as an Serum Response Factor-interacting protein, enhances Serum Response Factor DNA binding activity, and is required for endothelial cell migration and tube formation to regulate angiogenesis. PMID: 26799706
SMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma. PMID: 25644430
effects of gene mutations on ventricular development PMID: 12858532
HDGF functions as a transcriptional repressor of the SMYD1 gene through interaction with the transcriptional corepressor CtBP. PMID: 19162039

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

Class V-like SAM-binding methyltransferase superfamily

Tissue Specificity

Expression seems mostly restricted to heart and skeletal muscle.

Database Links

HGNC: 20986

OMIM: 606846

KEGG: hsa:150572

STRING: 9606.ENSP00000393453

UniGene: Hs.516176

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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