SMYD1 Antibody

Code CSB-PA021862GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
SMYD1
Alternative Names
BOP antibody; CD8 beta opposite antibody; CD8b opposite antibody; Histone lysine N methyltransferase SMYD1 antibody; KMT3D antibody; SET and MYND domain containing 1 antibody; SET and MYND domain-containing protein 1 antibody; SMYD1 antibody; SMYD1_HUMAN antibody; Zinc finger MYND domain containing 18 antibody; ZMYND18 antibody; ZMYND22 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Human SMYD1-Specific
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.
Gene References into Functions
  1. We present genetic and statistical evidence that the R320Q substitution in SMYD1 underlies an inherited form of the AnWj-negative blood group phenotype. The mechanism by which the mutation leads to this phenotype remains to be determined. PMID: 29956848
  2. SMYD1 serves as an Serum Response Factor-interacting protein, enhances Serum Response Factor DNA binding activity, and is required for endothelial cell migration and tube formation to regulate angiogenesis. PMID: 26799706
  3. SMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma. PMID: 25644430
  4. effects of gene mutations on ventricular development PMID: 12858532
  5. HDGF functions as a transcriptional repressor of the SMYD1 gene through interaction with the transcriptional corepressor CtBP. PMID: 19162039

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Subcellular Location
Cytoplasm. Nucleus.
Protein Families
Class V-like SAM-binding methyltransferase superfamily
Tissue Specificity
Expression seems mostly restricted to heart and skeletal muscle.
Database Links

HGNC: 20986

OMIM: 606846

KEGG: hsa:150572

STRING: 9606.ENSP00000393453

UniGene: Hs.516176

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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