SNIP1 Antibody

1. these data demonstrated a novel mechanism whereby SNIP1 regulates intestinal inflammation through modulating intestinal epithelial barrier function PMID: 29426045
2. SUMOylation of SNIP1 leads to the loss of SNIP1-mediated inhibition on expression of the TGF-beta target genes PAI-1 and MMP2 and eventually enhances TGF-beta-regulated cell migration and invasion. PMID: 27703003
3. Involvement of SNIP1 in progression of lung cancer by regulating the RB/HDAC1 interaction. PMID: 23932364
4. SNIP1 in cells strongly activated the heat shock element signaling pathway, and SNIP1 might selectively regulate the transcription of some heat shock proteins through associating with heat shock elements PMID: 22020748
5. Study identified sequence variants in the known disease-causing genes SLC6A3 and FLVCR1, and present evidence to strongly support the pathogenicity of variants identified in TUBGCP6, BRAT1, SNIP1, CRADD, and HARS. PMID: 22279524
6. overexpression of HIF-1alpha, TWIST2 or SNIP1 correlated with poor disease-free survival in patients with tongue squamous cell carcinoma PMID: 21167768
7. define both a new function for SNIP1 and identify a previously unrecognized regulator of the cell cycle and cyclin D1 expression PMID: 15378006
8. Smad-binding peptide aptamers can be developed to selectively inhibit TGF-beta-induced gene expression. PMID: 15750622
9. SNIP1 functions as a regulator of c-Myc activity, binding the N c-Myc N terminus through its C terminus, and that SNIP1 enhances the transcriptional activity of c-Myc by stabilizing it against proteosomal degradation and bridging the c-Myc/p300 complex. PMID: 17157259
10. SNIP1, the human homolog of DDL, is involved in miRNA biogenesis and interacts with Drosha PMID: 18632581
11. Study shows a novel mechanism regulating Cyclin D1 expression and offers new insight into the role of SNIP1 and associated proteins as regulators of proliferation and cancer. PMID: 18794151

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HGNC: 30587

OMIM: 608241

KEGG: hsa:79753

STRING: 9606.ENSP00000296215

UniGene: Hs.47232