SPC25 Antibody

Datasheet

Code	CSB-PA881019LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA881019LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SPC25 Polyclonal antibody

Uniprot No.

Q9HBM1

Target Names

SPC25

Alternative Names

AD024 antibody; hSpc25 antibody; Kinetochore protein Spc25 antibody; SPBC25 antibody; SPC25 antibody; SPC25_HUMAN antibody; spindle pole body component 25 homolog antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Kinetochore protein Spc25 protein (1-224AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SPC25 Antibody (Product code: CSB-PA881019LA01HU) is Non-conjugated. For SPC25 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA881019LB01HU	SPC25 Antibody, HRP conjugated	ELISA
FITC	CSB-PA881019LC01HU	SPC25 Antibody, FITC conjugated
Biotin	CSB-PA881019LD01HU	SPC25 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.

Gene References into Functions

SPC25 overexpression significantly increased the cancer stem cell properties and invasion of A549 cells. PMID: 29432994
SPC25 expressed by extracellular matrix stiffening is required for lung cancer cell proliferation. PMID: 29709477
SPC25 overexpression is associated with Breast Cancer. PMID: 27197203
hSPC25 is an essential kinetochore component that plays a significant role in proper execution of mitotic events PMID: 14699129
the Spc24, Spc25, Nuf2, and Ndc80/Hec1 complex is a faithful copy of the endogenous Ndc80 complex PMID: 15961401

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Subcellular Location

Nucleus. Chromosome, centromere, kinetochore.

Protein Families

SPC25 family

Database Links

HGNC: 24031

OMIM: 609395

KEGG: hsa:57405

STRING: 9606.ENSP00000282074

UniGene: Hs.421956

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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