SPC25 Antibody, HRP conjugated

Code CSB-PA881019LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SPC25 Polyclonal antibody
Uniprot No.
Target Names
SPC25
Alternative Names
AD024 antibody; hSpc25 antibody; Kinetochore protein Spc25 antibody; SPBC25 antibody; SPC25 antibody; SPC25_HUMAN antibody; spindle pole body component 25 homolog antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Kinetochore protein Spc25 protein (1-224AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
Gene References into Functions
  1. SPC25 overexpression significantly increased the cancer stem cell properties and invasion of A549 cells. PMID: 29432994
  2. SPC25 expressed by extracellular matrix stiffening is required for lung cancer cell proliferation. PMID: 29709477
  3. SPC25 overexpression is associated with Breast Cancer. PMID: 27197203
  4. hSPC25 is an essential kinetochore component that plays a significant role in proper execution of mitotic events PMID: 14699129
  5. the Spc24, Spc25, Nuf2, and Ndc80/Hec1 complex is a faithful copy of the endogenous Ndc80 complex PMID: 15961401

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Subcellular Location
Nucleus. Chromosome, centromere, kinetochore.
Protein Families
SPC25 family
Database Links

HGNC: 24031

OMIM: 609395

KEGG: hsa:57405

STRING: 9606.ENSP00000282074

UniGene: Hs.421956

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