SRRM2 Antibody

Code CSB-PA892369LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA892369LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SRRM2 Polyclonal antibody
Uniprot No.
Target Names
SRRM2
Alternative Names
300 kDa nuclear matrix antigen antibody; CWC21 antibody; KIAA0324 antibody; Ser/Arg-related nuclear matrix protein of 300 kDa antibody; Serine/arginine repetitive matrix protein 2 antibody; Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa antibody; Splicing coactivator subunit SRm300 antibody; SR-related nuclear matrix protein of 300 kDa antibody; SRL300 antibody; SRM300 antibody; SRRM2 antibody; SRRM2_HUMAN antibody; Tax-responsive enhancer element-binding protein 803 antibody; TaxREB803 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Serine/arginine repetitive matrix protein 2 protein (248-462AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SRRM2 Antibody (Product code: CSB-PA892369LA01HU) is Non-conjugated. For SRRM2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA892369LB01HU SRRM2 Antibody, HRP conjugated ELISA
FITC CSB-PA892369LC01HU SRRM2 Antibody, FITC conjugated
Biotin CSB-PA892369LD01HU SRRM2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Required for pre-mRNA splicing as component of the spliceosome.
Gene References into Functions
  1. cellular complexes comprising cactin, DHX8 and SRRM2 sustain precise chromosome segregation, genome stability and cell proliferation by allowing faithful splicing of specific pre-mRNAs. PMID: 28062851
  2. The S346F mutation in SRRM2 predisposes to papillary thyroid carcinoma by affecting alternative splicing of unidentified downstream target genes. PMID: 26135620
  3. Data show that the consistent dysregulation of the RNA splicing factor SRRM2 in two different PD neuronal sources and in PD blood makes SRRM2 a strong candidate gene for PD and draws attention to the role of RNA splicing in the disease. PMID: 20161708
  4. results suggest multiple functions for Cwc21/SRm300 in the splicing process, including an important role in the activation of splicing in association with Isy1. PMID: 19789211
  5. demonstrate that SRm300, the only serine arginine-related protein known to be at the core of human catalytic spliceosomes, is a functional ortholog of Cwc21p, also interacting directly with Prp8p and Snu114p. PMID: 19854871

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Subcellular Location
Nucleus. Nucleus speckle.
Protein Families
CWC21 family
Tissue Specificity
Expressed in liver, placenta, and white blood cells.
Database Links

HGNC: 16639

OMIM: 606032

KEGG: hsa:23524

STRING: 9606.ENSP00000301740

UniGene: Hs.433343

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