SRRT Antibody

1. Study present the human ARS2 crystal structure, which exhibits similarities and metazoan-specific differences to the plant homologue SERRATE, most notably an additional RRM domain. RRM domain is required to bind RNA, whereas a basic patch in the C-terminal leg of ARS2 mediates the interaction with FLASH. PMID: 29703953
2. define two mutually exclusive complexes CBC-NELF-E and CBC-ARS2-PHAX, which likely act in respectively earlier and later phases of transcription PMID: 29101316
3. ARS2 depletion negatively impacts levels of promoter-proximal RNA polymerase II at protein-coding genes. It is involved in transcription termination events within first introns of pc genes. ARS2 plays a role in transcription termination-coupled RNA turnover at short transcription units like snRNA-, replication-dependent histone-, promoter upstream transcript- and enhancer RNA-loci. PMID: 28973446
4. 2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-kappaB, AP-1 and MAPK pathways in human proximal tubular cells. PMID: 26404762
5. Ars2 is overexpressed in HCC and may have prognostic value; it might play an important role in HCC proliferation and miR-21 expression. PMID: 24272391
6. Ars2 contributes to histone mRNA 3' end formation and expression and these functional properties of Ars2 are negatively regulated by interaction with 7SK RNA. PMID: 22244333
7. These data indicate ARS2 is essential for early mammalian development and is likely involved in an essential cellular process. PMID: 18086880
8. These findings provide evidence for a role for Ars2 in RNA interference regulation during cell proliferation. PMID: 19632182
9. Validated occurrence of an unusual TG 3' splice site in intron 17 (NM_015908). PMID: 17672918
10. Nomenclature. Original paper and GenBank submission by Rossman and Wang (1999) called the gene Asr2 (arsenite resistance protein 2) as opposed to Ars2 (arsenate resistance protein 2). PMID: 10069470

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HGNC: 24101

OMIM: 614469

KEGG: hsa:51593

STRING: 9606.ENSP00000314491

UniGene: Hs.111801