ST6GALNAC6 Antibody, FITC conjugated

Code CSB-PA850251LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ST6GALNAC6 Polyclonal antibody
Uniprot No.
Target Names
ST6GALNAC6
Alternative Names
ST6GALNAC6 antibody; SIAT7F antibody; UNQ708/PRO1359 antibody; Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 antibody; EC 2.4.99.- antibody; GalNAc alpha-2,6-sialyltransferase VI antibody; ST6GalNAc VI antibody; ST6GalNAcVI antibody; hST6GalNAc VI antibody; Sialyltransferase 7F antibody; SIAT7-F antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 protein (65-333AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b. Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen. Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside).
Gene References into Functions
  1. novel substrate specificity of ST6GalNAc VI, which is responsible for the synthesis of disialyl Lea but not for alpha-series gangliosides in human colon tissues PMID: 12668675
  2. ST6GalNAc-VI and disialylgalactosylgloboside were found in proximal tubule epithelial cells in normal kidney tissues PMID: 17123352
Subcellular Location
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein Families
Glycosyltransferase 29 family
Tissue Specificity
Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines.
Database Links

HGNC: 23364

OMIM: 610135

KEGG: hsa:30815

STRING: 9606.ENSP00000291839

UniGene: Hs.109672

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