STARD13 Antibody

Code CSB-PA805513
Size US$297
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  • Western blot analysis of extracts from K562 cells, using STA13 antibody.
  • Immunofluorescence analysis of A549 cells, using STA13 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) STARD13 Polyclonal antibody
Uniprot No.
Target Names
STARD13
Alternative Names
46H23.2 antibody; ARHGAP37 antibody; Deleted in liver cancer 2 protein antibody; Deleted in liver cancer protein 2 antibody; DLC-2 antibody; DLC2 antibody; GT650 antibody; Rho GTPase activating protein on chromosome 13q12 antibody; Rho GTPase-activating protein antibody; STA13 antibody; STA13_HUMAN antibody; StAR related lipid transfer (START) domain containing 13 antibody; StAR-related lipid transfer protein 13 antibody; StARD13 antibody; START domain-containing protein 13 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from N-terminal of Human STA13.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB,IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IF 1:100-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.
Gene References into Functions
  1. Study elucidated StarD13 messenger RNA as a Competitive endogenous messenger RNA (ceRNA) in regulating migration and invasion of breast cancer cells. MicroRNA-125b was identified to induce metastasis of MCF-7 cells and bind with both StarD13 3'UTR and TP53INP1 3'UTR. Therefore, a ceRNA interaction between StarD13 and TP53INP1 mediated by competitively binding to miR-125b was indicated. PMID: 29146309
  2. Low STARD13 expression is associated with metastasis of breast cancer. PMID: 26985770
  3. miR-125b functions as an oncogene in gastric cancer and represents a new potential therapeutic target for gastric cancer. PMID: 27220320
  4. The tumor suppressor DLC2 and Kif1B are central components of a signaling network that guides spindle positioning, cell-cell adhesion and mitotic fidelity. PMID: 25518808
  5. Dimerization of DLC2 was required for its interaction with GKAP, which, in turn, potentiated GKAP self-association. PMID: 24938595
  6. Study describes STARD13 as a tumor suppressor playing a positive role in cancer motility. PMID: 24627003
  7. The present study further describes the role of StarD13 as a tumor suppressor as well as a Rho GAP. PMID: 24253896
  8. Importance of the regulation of RhoA activity in focal adhesions of astrocytoma cells and StarD13 is a GAP playing a major role in this process. PMID: 24333506
  9. In the present review, we discuss the family of RhoGTPases, their regulation and their RhoGAPs, focusing mainly on STARD13. [review] PMID: 23316797
  10. RhoGAP protein Stard13 is an essential regulator of pancreas tissue architecture in the mammalian embryo; Stard13 acts by regulating Rho signalling spatially and temporally during pancreas development. PMID: 23175628
  11. Authors detected an increase in p-ERK in StarD13 knockdown cells, uncovering a potential link between Rho GTPases and ERK activation. PMID: 22614672
  12. role of miR-125b in pro-metastasis by targeting STARD13 PMID: 22693547
  13. DLC2 inhibits the activity of Raf-1-ERK1/2-p70S6K via its RhoGAP function, resulting in the suppression of cell growth. PMID: 20629949
  14. has GAP activity specific for RhoA and Cdc42; inhibits the Rho mediated assembly of actin stress fibers in cultured cells and is underexpressed in hepatocellular carcinoma tissues PMID: 12531887
  15. underexpression is associated with poor prognosis in patients with hepatocellular carcinoma PMID: 18651974

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Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet.
Tissue Specificity
Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.
Database Links

HGNC: 19164

OMIM: 609866

KEGG: hsa:90627

STRING: 9606.ENSP00000338785

UniGene: Hs.156551

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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